Pluripotency of mesenchymal stem cells derived from adult marrow

We report here that cells co-purifying with mesenchymal stem cells--termed here multipotent adult progenitor cells or MAPCs--differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro. When inje...

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Bibliographic Details
Published in:Nature (London) 2002-07, Vol.418 (6893), p.41-49
Main Authors: Jiang, Yuehua, Jahagirdar, Balkrishna N, Reinhardt, R. Lee, Schwartz, Robert E, Keene, C. Dirk, Ortiz-Gonzalez, Xilma R, Reyes, Morayma, Lenvik, Todd, Lund, Troy, Blackstad, Mark, Du, Jingbo, Aldrich, Sara, Lisberg, Aaron, Low, Walter C, Largaespada, David A, Verfaillie, Catherine M
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Biological and medical sciences
Blastocyst - cytology
Bone marrow
Bone Marrow Cells - cytology
Bone Marrow Transplantation
Cell Differentiation
Cell differentiation, maturation, development, hematopoiesis
Cell Division
Cell Lineage
Cell physiology
Cell Transplantation
Cell- and Tissue-Based Therapy
Cellular biology
Ectoderm - cytology
Embryos
Endoderm - cytology
Endothelium - cytology
Fundamental and applied biological sciences. Psychology
Gastrointestinal tract
Humans
Intestines - cytology
Liver - cytology
Lung - cytology
Mesoderm - cytology
Mesoderm - transplantation
Mice
Mice, Inbred NOD
Mice, SCID
Molecular and cellular biology
Organ Specificity
Radiation Chimera
Rats
Stem Cell Transplantation
Stem cells
Stem Cells - cytology
Tissues
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Summary:We report here that cells co-purifying with mesenchymal stem cells--termed here multipotent adult progenitor cells or MAPCs--differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro. When injected into an early blastocyst, single MAPCs contribute to most, if not all, somatic cell types. On transplantation into a non-irradiated host, MAPCs engraft and differentiate to the haematopoietic lineage, in addition to the epithelium of liver, lung and gut. Engraftment in the haematopoietic system as well as the gastrointestinal tract is increased when MAPCs are transplanted in a minimally irradiated host. As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature00870