Practical guide for accurate quantitative solution state NMR analysis

A practical guide to experimental conditions such as statistical variation of signal intensity on quantitative solution state nuclear magnetic resonanace (NMR) analysis is discussed and presented. Statistical analysis showed that there is a relationship between a targeted precision and practical pul...

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Bibliographic Details
Published in:Metrologia 2004-06, Vol.41 (3), p.213-218
Main Authors: Saito, Takeshi, Nakaie, Sachiko, Kinoshita, Miyuki, Ihara, Toshihide
Format: Article
Language:English
Subjects:
Experiments
NMR
Nuclear magnetic resonance
Spectrum analysis
Statistical analysis
Online Access:Get full text
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Summary:A practical guide to experimental conditions such as statistical variation of signal intensity on quantitative solution state nuclear magnetic resonanace (NMR) analysis is discussed and presented. Statistical analysis showed that there is a relationship between a targeted precision and practical pulse intervals. The bandwidth of the audio filter needs to be set so that all the signals of interest fall into 80% of the centre part of the filter. When fulfilling these conditions, the relative standard deviation (RSD) of a signal area in repeated experiments can be estimated by determining the signal-to-noise ratio (SN) of a single spectrum. When the SN reached 1000, the RSD became constant with increasing SN. With such a condition, accuracy better than 1% should be obtained with quantitative NMR. [PUBLICATION ABSTRACT]
ISSN:0026-1394
1681-7575
DOI:10.1088/0026-1394/41/3/015