Postsynaptic Signaling and Plasticity Mechanisms

In excitatory synapses of the brain, specific receptors in the postsynaptic membrane lie ready to respond to the release of the neurotransmitter glutamate from the presynaptic terminal. Upon stimulation, these glutamate receptors activate multiple biochemical pathways that transduce signals into the...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2002-10, Vol.298 (5594), p.776-780
Main Authors: Sheng, Morgan, Kim, Myung Jong
Format: Article
Language:English
Subjects:
Amino acid neurotransmitters
Animals
Biochemistry
Brain
Brain - physiology
Brain - ultrastructure
Brain research
Calcium
Endocytosis
Exocytosis
Long term depression
Long term potentiation
Long-Term Synaptic Depression
Neuronal Plasticity
Neurons
Neurons - physiology
Neuroscience
Neurotransmitters
Phosphatases
Physiological regulation
Plasticity
Receptors
Receptors, AMPA - physiology
Receptors, N-Methyl-D-Aspartate - physiology
Reviews
Scientific Concepts
Signal Transduction
Synapses
Synapses - physiology
Synaptic Membranes - metabolism
Synaptic Transmission
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In excitatory synapses of the brain, specific receptors in the postsynaptic membrane lie ready to respond to the release of the neurotransmitter glutamate from the presynaptic terminal. Upon stimulation, these glutamate receptors activate multiple biochemical pathways that transduce signals into the postsynaptic neuron. Different kinds of synaptic activity elicit different patterns of postsynaptic signals that lead to short- or long-lasting strengthening or weakening of synaptic transmission. The complex molecular mechanisms that underlie postsynaptic signaling and plasticity are beginning to emerge.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1075333