Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by FcGammaRIIB1. (receptor for the Fc region of IgG)

Coligation of the Fc receptor on B cells, FcgammaRIIB1, with the B cell antigen receptor (BCR) leads to abortive BCR signaling. A study shows that the FcgammaRIIB1 recruits the phosphotyrosine phosphatase PTP1C after BCR coligation.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1995-04, Vol.268 (5208), p.293-293
Main Authors: D'Ambrosio, Daniele, Hippen, Keli L, Minskoff, Stacey A, Mellman, Ira, Pani, Giovanni, Siminovitch, Kathy A, Cambier, John C
Format: Article
Language:English
Subjects:
Autoimmunity
Cellular biology
Cellular signal transduction
Fc receptors
Immunity (Disease)
Individualized Instruction
Inhibition
Literary Devices
Proteins
Recruitment
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Description
Summary:Coligation of the Fc receptor on B cells, FcgammaRIIB1, with the B cell antigen receptor (BCR) leads to abortive BCR signaling. A study shows that the FcgammaRIIB1 recruits the phosphotyrosine phosphatase PTP1C after BCR coligation.
ISSN:0036-8075
1095-9203