Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2

To identify genetic determinants of hypoxic cell death, we screened for hypoxia-resistant (Hyp) mutants in Caenorhabditis elegans and found that specific reduction-of-function (rf) mutants of daf-2, an insulin/insulinlike growth factor (IGF) receptor (INR) homolog gene, were profoundly Hyp. The hypo...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2002-06, Vol.296 (5577), p.2388-2391
Main Authors: Scott, Barbara A., Avidan, Michael S., Crowder, C. Michael
Format: Article
Language:English
Subjects:
3-Phosphoinositide-Dependent Protein Kinases
Adults
Ageing, cell death
Alleles
Animals
Anoxia
Axons - ultrastructure
Biological and medical sciences
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Caenorhabditis elegans - growth & development
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - physiology
Cell Death
Cell Nucleus - ultrastructure
Cell physiology
Cell Survival
Cellular biology
Climate
Effects of physical and chemical agents
Forkhead Transcription Factors
Fundamental and applied biological sciences. Psychology
Genes
Genes, Helminth
Genetic mutation
Genetics
Hypoxia
Hypoxia - genetics
Insulin
Insulin-like growth factors
Intestines - cytology
Intestines - metabolism
Longevity
Medical genetics
Molecular and cellular biology
Mortality
Movement
Muscles - cytology
Muscles - metabolism
Muscles - ultrastructure
Mutation
Mutation, Missense
Nematode larvae
Neurons
Neurons - cytology
Neurons - metabolism
Neurons - ultrastructure
Patient outcomes
Phenotype
Phenotypes
Phosphatidylinositol 3-Kinases
Protein-Serine-Threonine Kinases - metabolism
Protein-Tyrosine Kinases - genetics
Protein-Tyrosine Kinases - physiology
Receptor, Insulin - genetics
Receptor, Insulin - physiology
Receptors
Reporter genes
Signal Transduction
Somatomedins
Temperature
Transcription Factors - genetics
Transcription Factors - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c709t-d179342029dcae96230b32eab600228f043a154d64791df0211a73ce011bb6a63
cites cdi_FETCH-LOGICAL-c709t-d179342029dcae96230b32eab600228f043a154d64791df0211a73ce011bb6a63
container_end_page 2391
container_issue 5577
container_start_page 2388
container_title Science (American Association for the Advancement of Science)
container_volume 296
creator Scott, Barbara A.
Avidan, Michael S.
Crowder, C. Michael
description To identify genetic determinants of hypoxic cell death, we screened for hypoxia-resistant (Hyp) mutants in Caenorhabditis elegans and found that specific reduction-of-function (rf) mutants of daf-2, an insulin/insulinlike growth factor (IGF) receptor (INR) homolog gene, were profoundly Hyp. The hypoxia resistance was acutely inducible just before hypoxic exposure and was mediated through an AKT-1/PDK-1/forkhead transcription factor pathway overlapping with but distinct from signaling pathways regulating life-span and stress resistance. Selective neuronal and muscle expression of daf-2(+) restored hypoxic death, and daf-2(rf) prevented hypoxia-induced muscle and neuronal cell death, which demonstrates a potential for INR modulation in prophylaxis against hypoxic injury of neurons and myocytes.
doi_str_mv 10.1126/science.1072302
format article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_743416077</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A89079242</galeid><jstor_id>3077280</jstor_id><sourcerecordid>A89079242</sourcerecordid><originalsourceid>FETCH-LOGICAL-c709t-d179342029dcae96230b32eab600228f043a154d64791df0211a73ce011bb6a63</originalsourceid><addsrcrecordid>eNqN0t2r0zAYwOEiimdOr70RCYIfF6dbPtqmuZw77gOGg3PU25Kmb3s60mQ2LZz990ZWPEyGjlwU8j4tCf0FwWuCJ4TQZOpUDUbBhGBOGaZPghHBIg4FxexpMMKYJWGKeXwVvHBuh7GfCfY8uCIUJzGP4lFwdwtVr2VXW4NsiVaHvX2oFboB2d2j2qD5BIGGShqH8gPq7gGtjet1babr5QLdgoJ9Z1u0so3VtkI3s0VIXwbPSqkdvBqe4-D74su3-SrcbJfr-WwTKo5FFxaECxZRTEWhJIjEXyBnFGSeYExpWuKISRJHRRJxQYoSU0IkZwowIXmeyISNg4_H7-5b-7MH12VN7RRoLQ3Y3mU8YhFJMOdefvi3JGkSJen_IUn9gXkae_juL7izfWv8dTNKWCyiNGIeXR9RJTVktSlt10pVgYFWamugrP32LBWYCxpRz8Mz3K8Cmlqd859OvCcdPHSV7J3L1ndfL6bbHxfTz8tLabrcnNDrc1RZ7euCzHcx357w6ZGr1jrXQpnt27qR7SEjOPtdfjaUnw3l-zfeDj-kzxsoHv2QugfvByCdkrpspVG1e3SM-wZ8MuPgzdHtnC_7z5z5jmiK2S8LNgzh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213594843</pqid></control><display><type>article</type><title>Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2</title><source>Social Science Premium Collection</source><source>Science Online_科学在线</source><source>Alma/SFX Local Collection</source><source>Education Collection</source><creator>Scott, Barbara A. ; Avidan, Michael S. ; Crowder, C. Michael</creator><creatorcontrib>Scott, Barbara A. ; Avidan, Michael S. ; Crowder, C. Michael</creatorcontrib><description>To identify genetic determinants of hypoxic cell death, we screened for hypoxia-resistant (Hyp) mutants in Caenorhabditis elegans and found that specific reduction-of-function (rf) mutants of daf-2, an insulin/insulinlike growth factor (IGF) receptor (INR) homolog gene, were profoundly Hyp. The hypoxia resistance was acutely inducible just before hypoxic exposure and was mediated through an AKT-1/PDK-1/forkhead transcription factor pathway overlapping with but distinct from signaling pathways regulating life-span and stress resistance. Selective neuronal and muscle expression of daf-2(+) restored hypoxic death, and daf-2(rf) prevented hypoxia-induced muscle and neuronal cell death, which demonstrates a potential for INR modulation in prophylaxis against hypoxic injury of neurons and myocytes.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1072302</identifier><identifier>PMID: 12065745</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>3-Phosphoinositide-Dependent Protein Kinases ; Adults ; Ageing, cell death ; Alleles ; Animals ; Anoxia ; Axons - ultrastructure ; Biological and medical sciences ; Caenorhabditis elegans ; Caenorhabditis elegans - genetics ; Caenorhabditis elegans - growth &amp; development ; Caenorhabditis elegans - physiology ; Caenorhabditis elegans Proteins - genetics ; Caenorhabditis elegans Proteins - physiology ; Cell Death ; Cell Nucleus - ultrastructure ; Cell physiology ; Cell Survival ; Cellular biology ; Climate ; Effects of physical and chemical agents ; Forkhead Transcription Factors ; Fundamental and applied biological sciences. Psychology ; Genes ; Genes, Helminth ; Genetic mutation ; Genetics ; Hypoxia ; Hypoxia - genetics ; Insulin ; Insulin-like growth factors ; Intestines - cytology ; Intestines - metabolism ; Longevity ; Medical genetics ; Molecular and cellular biology ; Mortality ; Movement ; Muscles - cytology ; Muscles - metabolism ; Muscles - ultrastructure ; Mutation ; Mutation, Missense ; Nematode larvae ; Neurons ; Neurons - cytology ; Neurons - metabolism ; Neurons - ultrastructure ; Patient outcomes ; Phenotype ; Phenotypes ; Phosphatidylinositol 3-Kinases ; Protein-Serine-Threonine Kinases - metabolism ; Protein-Tyrosine Kinases - genetics ; Protein-Tyrosine Kinases - physiology ; Receptor, Insulin - genetics ; Receptor, Insulin - physiology ; Receptors ; Reporter genes ; Signal Transduction ; Somatomedins ; Temperature ; Transcription Factors - genetics ; Transcription Factors - physiology</subject><ispartof>Science (American Association for the Advancement of Science), 2002-06, Vol.296 (5577), p.2388-2391</ispartof><rights>Copyright 2002 American Association for the Advancement of Science</rights><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2002 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2002 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jun 28, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c709t-d179342029dcae96230b32eab600228f043a154d64791df0211a73ce011bb6a63</citedby><cites>FETCH-LOGICAL-c709t-d179342029dcae96230b32eab600228f043a154d64791df0211a73ce011bb6a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/213594843/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/213594843?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2884,2885,21378,21394,27924,27925,33611,33612,33877,33878,43733,43880,74093,74269</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=13786474$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12065745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scott, Barbara A.</creatorcontrib><creatorcontrib>Avidan, Michael S.</creatorcontrib><creatorcontrib>Crowder, C. Michael</creatorcontrib><title>Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>To identify genetic determinants of hypoxic cell death, we screened for hypoxia-resistant (Hyp) mutants in Caenorhabditis elegans and found that specific reduction-of-function (rf) mutants of daf-2, an insulin/insulinlike growth factor (IGF) receptor (INR) homolog gene, were profoundly Hyp. The hypoxia resistance was acutely inducible just before hypoxic exposure and was mediated through an AKT-1/PDK-1/forkhead transcription factor pathway overlapping with but distinct from signaling pathways regulating life-span and stress resistance. Selective neuronal and muscle expression of daf-2(+) restored hypoxic death, and daf-2(rf) prevented hypoxia-induced muscle and neuronal cell death, which demonstrates a potential for INR modulation in prophylaxis against hypoxic injury of neurons and myocytes.</description><subject>3-Phosphoinositide-Dependent Protein Kinases</subject><subject>Adults</subject><subject>Ageing, cell death</subject><subject>Alleles</subject><subject>Animals</subject><subject>Anoxia</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans - growth &amp; development</subject><subject>Caenorhabditis elegans - physiology</subject><subject>Caenorhabditis elegans Proteins - genetics</subject><subject>Caenorhabditis elegans Proteins - physiology</subject><subject>Cell Death</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Cell physiology</subject><subject>Cell Survival</subject><subject>Cellular biology</subject><subject>Climate</subject><subject>Effects of physical and chemical agents</subject><subject>Forkhead Transcription Factors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes</subject><subject>Genes, Helminth</subject><subject>Genetic mutation</subject><subject>Genetics</subject><subject>Hypoxia</subject><subject>Hypoxia - genetics</subject><subject>Insulin</subject><subject>Insulin-like growth factors</subject><subject>Intestines - cytology</subject><subject>Intestines - metabolism</subject><subject>Longevity</subject><subject>Medical genetics</subject><subject>Molecular and cellular biology</subject><subject>Mortality</subject><subject>Movement</subject><subject>Muscles - cytology</subject><subject>Muscles - metabolism</subject><subject>Muscles - ultrastructure</subject><subject>Mutation</subject><subject>Mutation, Missense</subject><subject>Nematode larvae</subject><subject>Neurons</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Neurons - ultrastructure</subject><subject>Patient outcomes</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Phosphatidylinositol 3-Kinases</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Protein-Tyrosine Kinases - genetics</subject><subject>Protein-Tyrosine Kinases - physiology</subject><subject>Receptor, Insulin - genetics</subject><subject>Receptor, Insulin - physiology</subject><subject>Receptors</subject><subject>Reporter genes</subject><subject>Signal Transduction</subject><subject>Somatomedins</subject><subject>Temperature</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - physiology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>CJNVE</sourceid><sourceid>M0P</sourceid><recordid>eNqN0t2r0zAYwOEiimdOr70RCYIfF6dbPtqmuZw77gOGg3PU25Kmb3s60mQ2LZz990ZWPEyGjlwU8j4tCf0FwWuCJ4TQZOpUDUbBhGBOGaZPghHBIg4FxexpMMKYJWGKeXwVvHBuh7GfCfY8uCIUJzGP4lFwdwtVr2VXW4NsiVaHvX2oFboB2d2j2qD5BIGGShqH8gPq7gGtjet1babr5QLdgoJ9Z1u0so3VtkI3s0VIXwbPSqkdvBqe4-D74su3-SrcbJfr-WwTKo5FFxaECxZRTEWhJIjEXyBnFGSeYExpWuKISRJHRRJxQYoSU0IkZwowIXmeyISNg4_H7-5b-7MH12VN7RRoLQ3Y3mU8YhFJMOdefvi3JGkSJen_IUn9gXkae_juL7izfWv8dTNKWCyiNGIeXR9RJTVktSlt10pVgYFWamugrP32LBWYCxpRz8Mz3K8Cmlqd859OvCcdPHSV7J3L1ndfL6bbHxfTz8tLabrcnNDrc1RZ7euCzHcx357w6ZGr1jrXQpnt27qR7SEjOPtdfjaUnw3l-zfeDj-kzxsoHv2QugfvByCdkrpspVG1e3SM-wZ8MuPgzdHtnC_7z5z5jmiK2S8LNgzh</recordid><startdate>20020628</startdate><enddate>20020628</enddate><creator>Scott, Barbara A.</creator><creator>Avidan, Michael S.</creator><creator>Crowder, C. Michael</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20020628</creationdate><title>Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2</title><author>Scott, Barbara A. ; Avidan, Michael S. ; Crowder, C. Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c709t-d179342029dcae96230b32eab600228f043a154d64791df0211a73ce011bb6a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>3-Phosphoinositide-Dependent Protein Kinases</topic><topic>Adults</topic><topic>Ageing, cell death</topic><topic>Alleles</topic><topic>Animals</topic><topic>Anoxia</topic><topic>Axons - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Caenorhabditis elegans - growth &amp; development</topic><topic>Caenorhabditis elegans - physiology</topic><topic>Caenorhabditis elegans Proteins - genetics</topic><topic>Caenorhabditis elegans Proteins - physiology</topic><topic>Cell Death</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Cell physiology</topic><topic>Cell Survival</topic><topic>Cellular biology</topic><topic>Climate</topic><topic>Effects of physical and chemical agents</topic><topic>Forkhead Transcription Factors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes</topic><topic>Genes, Helminth</topic><topic>Genetic mutation</topic><topic>Genetics</topic><topic>Hypoxia</topic><topic>Hypoxia - genetics</topic><topic>Insulin</topic><topic>Insulin-like growth factors</topic><topic>Intestines - cytology</topic><topic>Intestines - metabolism</topic><topic>Longevity</topic><topic>Medical genetics</topic><topic>Molecular and cellular biology</topic><topic>Mortality</topic><topic>Movement</topic><topic>Muscles - cytology</topic><topic>Muscles - metabolism</topic><topic>Muscles - ultrastructure</topic><topic>Mutation</topic><topic>Mutation, Missense</topic><topic>Nematode larvae</topic><topic>Neurons</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Neurons - ultrastructure</topic><topic>Patient outcomes</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Phosphatidylinositol 3-Kinases</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Protein-Tyrosine Kinases - genetics</topic><topic>Protein-Tyrosine Kinases - physiology</topic><topic>Receptor, Insulin - genetics</topic><topic>Receptor, Insulin - physiology</topic><topic>Receptors</topic><topic>Reporter genes</topic><topic>Signal Transduction</topic><topic>Somatomedins</topic><topic>Temperature</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scott, Barbara A.</creatorcontrib><creatorcontrib>Avidan, Michael S.</creatorcontrib><creatorcontrib>Crowder, C. Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale in Context : Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Databases</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric &amp; Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts – Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Agricultural Science Database</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>ProQuest Science Journals</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric &amp; Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scott, Barbara A.</au><au>Avidan, Michael S.</au><au>Crowder, C. Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2002-06-28</date><risdate>2002</risdate><volume>296</volume><issue>5577</issue><spage>2388</spage><epage>2391</epage><pages>2388-2391</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>To identify genetic determinants of hypoxic cell death, we screened for hypoxia-resistant (Hyp) mutants in Caenorhabditis elegans and found that specific reduction-of-function (rf) mutants of daf-2, an insulin/insulinlike growth factor (IGF) receptor (INR) homolog gene, were profoundly Hyp. The hypoxia resistance was acutely inducible just before hypoxic exposure and was mediated through an AKT-1/PDK-1/forkhead transcription factor pathway overlapping with but distinct from signaling pathways regulating life-span and stress resistance. Selective neuronal and muscle expression of daf-2(+) restored hypoxic death, and daf-2(rf) prevented hypoxia-induced muscle and neuronal cell death, which demonstrates a potential for INR modulation in prophylaxis against hypoxic injury of neurons and myocytes.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>12065745</pmid><doi>10.1126/science.1072302</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 2002-06, Vol.296 (5577), p.2388-2391
issn 0036-8075
1095-9203
language eng
recordid cdi_proquest_miscellaneous_743416077
source Social Science Premium Collection; Science Online_科学在线; Alma/SFX Local Collection; Education Collection
subjects 3-Phosphoinositide-Dependent Protein Kinases
Adults
Ageing, cell death
Alleles
Animals
Anoxia
Axons - ultrastructure
Biological and medical sciences
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Caenorhabditis elegans - growth & development
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - physiology
Cell Death
Cell Nucleus - ultrastructure
Cell physiology
Cell Survival
Cellular biology
Climate
Effects of physical and chemical agents
Forkhead Transcription Factors
Fundamental and applied biological sciences. Psychology
Genes
Genes, Helminth
Genetic mutation
Genetics
Hypoxia
Hypoxia - genetics
Insulin
Insulin-like growth factors
Intestines - cytology
Intestines - metabolism
Longevity
Medical genetics
Molecular and cellular biology
Mortality
Movement
Muscles - cytology
Muscles - metabolism
Muscles - ultrastructure
Mutation
Mutation, Missense
Nematode larvae
Neurons
Neurons - cytology
Neurons - metabolism
Neurons - ultrastructure
Patient outcomes
Phenotype
Phenotypes
Phosphatidylinositol 3-Kinases
Protein-Serine-Threonine Kinases - metabolism
Protein-Tyrosine Kinases - genetics
Protein-Tyrosine Kinases - physiology
Receptor, Insulin - genetics
Receptor, Insulin - physiology
Receptors
Reporter genes
Signal Transduction
Somatomedins
Temperature
Transcription Factors - genetics
Transcription Factors - physiology
title Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T02%3A01%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20Hypoxic%20Death%20in%20C.%20elegans%20by%20the%20Insulin/IGF%20Receptor%20Homolog%20DAF-2&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Scott,%20Barbara%20A.&rft.date=2002-06-28&rft.volume=296&rft.issue=5577&rft.spage=2388&rft.epage=2391&rft.pages=2388-2391&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1072302&rft_dat=%3Cgale_proqu%3EA89079242%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c709t-d179342029dcae96230b32eab600228f043a154d64791df0211a73ce011bb6a63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=213594843&rft_id=info:pmid/12065745&rft_galeid=A89079242&rft_jstor_id=3077280&rfr_iscdi=true