Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcγRIIB

Ono et al show that inhibitory signalling by FcgammaRIIB does not require the SH2-domain-containing protein tyrosine phosphatase, SHP-1, in mast cells and results in the recruitment of the SH2-domain-containing inositol polyphosphate 5-phosphatase, SHIP, to the tyrosine-phosphorylated 13-amino-acid...

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Bibliographic Details
Published in:Nature (London) 1996-09, Vol.383 (6597), p.263-266
Main Authors: ONO, M, BOLLAND, S, TEMPST, P, RAVETCH, J. V
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immune system
Immunity (Disease)
Immunobiology
Modulation of the immune response (stimulation, suppression)
Molecular biology
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Summary:Ono et al show that inhibitory signalling by FcgammaRIIB does not require the SH2-domain-containing protein tyrosine phosphatase, SHP-1, in mast cells and results in the recruitment of the SH2-domain-containing inositol polyphosphate 5-phosphatase, SHIP, to the tyrosine-phosphorylated 13-amino-acid inhibitory motif of FcgammaRIIB in both B cells and mast cells.
ISSN:0028-0836
1476-4687
DOI:10.1038/383263a0