Relapse to Cocaine-Seeking after Hippocampal Theta Burst Stimulation

Treatment efforts for cocaine addiction are hampered by high relapse rates. To map brain areas underlying relapse, we used electrical brain stimulation and intracranial injection of pharmacological compounds after extinction of cocaine self-administration behavior in rats. Electrical stimulation of...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2001-05, Vol.292 (5519), p.1175-1178
Main Authors: Vorel, Stanislav R., Liu, Xinhe, Hayes, Robert J., Spector, Jordan A., Gardner, Eliot L.
Format: Article
Language:English
Subjects:
Animals
Behavioral neuroscience
Biological and medical sciences
Brain
Cocaine
Cocaine - administration & dosage
Cocaine - pharmacology
Cocaine abuse
Cocaine-Related Disorders - physiopathology
Cocaine-Related Disorders - prevention & control
Conditioning, Operant - drug effects
Conditioning, Operant - physiology
Control Groups
Dopamine - physiology
Drug abusers
Drug addiction
Drug addictions
Drug addicts
Electric Stimulation
Electrical stimulation
Electrodes
Excitatory Amino Acid Agonists - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
Extinction, Psychological - drug effects
Extinction, Psychological - physiology
Glutamic Acid - physiology
Hippocampus
Hippocampus - cytology
Hippocampus - physiology
Injections, Intravenous
Kynurenic Acid - pharmacology
Medial forebrain bundle
Medial Forebrain Bundle - cytology
Medial Forebrain Bundle - drug effects
Medial Forebrain Bundle - physiology
Medical sciences
Memory - physiology
Mental stimulation
N-Methylaspartate - pharmacology
Neurology
Neurons
Physiological stimulation
Positive Reinforcement
Rats
Rats, Long-Evans
Recurrence
Relapse
Reward
Self Administration
Stimuli
Synaptic Transmission - drug effects
Theta Rhythm
Toxicology
Ventral tegmental area
Ventral Tegmental Area - cytology
Ventral Tegmental Area - drug effects
Ventral Tegmental Area - physiology
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Summary:Treatment efforts for cocaine addiction are hampered by high relapse rates. To map brain areas underlying relapse, we used electrical brain stimulation and intracranial injection of pharmacological compounds after extinction of cocaine self-administration behavior in rats. Electrical stimulation of the hippocampus containing glutamatergic fibers, but not the medial forebrain bundle containing dopaminergic fibers, elicited cocaine-seeking behavior dependent on glutamate in the ventral tegmental area. This suggests a role for glutamatergic neurotransmission in relapse to cocaine abuse. The medial forebrain bundle electrodes supported intense electrical self-stimulation. These findings suggest a dissociation of neural systems subserving positive reinforcement (self-stimulation) and incentive motivation (relapse).
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1058043