Role of Anthocyanidin Reductase, Encoded by BANYULS in Plant Flavonoid Biosynthesis

Condensed tannins (CTs) are flavonoid oligomers, many of which have beneficial effects on animal and human health. The flavanol (-)-epicatechin is a component of many CTs and contributes to flavor and astringency in tea and wine. We show that the BANYULS (BAN) genes from Arabidopsis thaliana and Med...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2003-01, Vol.299 (5605), p.396-399
Main Authors: Xie, De-Yu, Sharma, Shashi B., Paiva, Nancy L., Ferreira, Daneel, Dixon, Richard A.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Anthocyanin
Anthocyanins
Anthocyanins - biosynthesis
Anthocyanins - chemistry
Anthocyanins - metabolism
Arabidopsis - enzymology
Arabidopsis - genetics
Arabidopsis Proteins
Bioflavonoids
Biological and medical sciences
Biosynthesis
Botany
Catechin - metabolism
Circular Dichroism
Enzymes
Flavones
Flavonoids
Flowers & plants
Fundamental and applied biological sciences. Psychology
Genes
Genes, Plant
Leaves
Magnetic Resonance Spectroscopy
Medicago - enzymology
Medicago - genetics
Metabolism
Metabolism. Physicochemical requirements
Molecular Sequence Data
NAD - metabolism
NADH, NADPH Oxidoreductases - genetics
NADH, NADPH Oxidoreductases - metabolism
NADP - metabolism
Nicotiana - genetics
Nutritional aspects
Oxidation-Reduction
Oxygenases - metabolism
Petals
Plant cells
Plant physiology and development
Plants
Plants, Genetically Modified
Proanthocyanidins
Recombinant Proteins - metabolism
Scientific Concepts
Seeds - metabolism
Stereoisomerism
Tannins
Tannins - biosynthesis
Tannins - chemistry
Testa
Transgenic plants
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Summary:Condensed tannins (CTs) are flavonoid oligomers, many of which have beneficial effects on animal and human health. The flavanol (-)-epicatechin is a component of many CTs and contributes to flavor and astringency in tea and wine. We show that the BANYULS (BAN) genes from Arabidopsis thaliana and Medicago truncatula encode anthocyanidin reductase, which converts anthocyanidins to their corresponding 2,3-cis-flavan-3-ols. Ectopic expression of BAN in tobacco flower petals and Arabidopsis leaves results in loss of anthocyanins and accumulation of CTs.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1078540