RNA interference

A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cult...

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Bibliographic Details
Published in:Nature (London) 2002-07, Vol.418 (6894), p.244-251
Main Author: Hannon, Gregory J
Format: Article
Language:English
Subjects:
Animals
Caenorhabditis elegans
Cellular biology
Gene expression
Gene Silencing
Genes
Genetic aspects
Genetic Techniques
Genetics
Genome
Models, Genetic
Nucleic acids
Ribonucleic acid
RNA
RNA Processing, Post-Transcriptional
RNA, Double-Stranded - chemistry
RNA, Double-Stranded - genetics
RNA, Double-Stranded - metabolism
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Summary:A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. RNAi has been cultivated as a means to manipulate gene expression experimentally and to probe gene function on a whole-genome scale.
ISSN:0028-0836
1476-4687
DOI:10.1038/418244a