Successful treatment of extreme acute lead intoxication

Severe acute lead intoxications are rare and are associated with accidental or purposeful ingestion. There were only few cases of severe to fatal poisonings reported in literature in children. We report a case of acute lead intoxication in a child with extremely high lead blood level of 20.4 μmol/L...

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Published in:Toxicology and industrial health 2009-03, Vol.25 (2), p.137-140
Main Authors: Mikler, J, Banovcin, P, Jesenak, M, Hamzikova, J, Statelova, D
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Aminolevulinic Acid - blood
Antidotes - therapeutic use
Charcoal - therapeutic use
Chelating Agents - therapeutic use
Edetic Acid - therapeutic use
Female
Humans
Lead - metabolism
Lead Poisoning - metabolism
Lead Poisoning - therapy
Nitrates - metabolism
Nitrates - poisoning
Suicide, Attempted
Therapeutic Irrigation
Treatment Outcome
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cited_by cdi_FETCH-LOGICAL-c487t-882e469e6e4cc6b92a77007966c526e74f80462b6809dcc57648a81e73f7be93
cites cdi_FETCH-LOGICAL-c487t-882e469e6e4cc6b92a77007966c526e74f80462b6809dcc57648a81e73f7be93
container_end_page 140
container_issue 2
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container_title Toxicology and industrial health
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creator Mikler, J
Banovcin, P
Jesenak, M
Hamzikova, J
Statelova, D
description Severe acute lead intoxications are rare and are associated with accidental or purposeful ingestion. There were only few cases of severe to fatal poisonings reported in literature in children. We report a case of acute lead intoxication in a child with extremely high lead blood level of 20.4 μmol/L (422.7 μg/dL), who was treated with chelation and in whom significant organ dysfunction did not develop. Documented significant high level above 3.37 μmol/L (corresponding to 70 μg/dL) in this patient persisted for approximately 24 h. Adequate, single or combined chelatation therapy in early phase of acute lead poisoning is essential for the further patient’s outcome.
doi_str_mv 10.1177/0748233709104759
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subjects Acute Disease
Adolescent
Aminolevulinic Acid - blood
Antidotes - therapeutic use
Charcoal - therapeutic use
Chelating Agents - therapeutic use
Edetic Acid - therapeutic use
Female
Humans
Lead - metabolism
Lead Poisoning - metabolism
Lead Poisoning - therapy
Nitrates - metabolism
Nitrates - poisoning
Suicide, Attempted
Therapeutic Irrigation
Treatment Outcome
title Successful treatment of extreme acute lead intoxication
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