Scanning Human Gene Deserts for Long-Range Enhancers

Nobrega et al focuses on scanning human gene deserts for long-range enhancers. The demonstration that several enhancers reside in gene deserts highlights that these regions can indeed serve as reservoirs for sequence elements containing important functions. Observations gathered have implications fo...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2003-10, Vol.302 (5644), p.413-413
Main Authors: Nobrega, Marcelo A., Ovcharenko, Ivan, Afzal, Veena, Rubin, Edward M.
Format: Article
Language:English
Subjects:
Animals
Anura - genetics
Base Sequence
Brevia
Conserved Sequence
Developmental Stages
DNA, Intergenic
Drosophila Proteins
Enhancer Elements, Genetic
Evolution, Molecular
Gene expression
Gene Expression Regulation
Genes
Genes, Reporter
Genetic regulation
Genomes
Genomics
Humans
Introns
Mice
Mice, Transgenic
Nuclear Proteins - genetics
Synteny
Takifugu - genetics
Technical Assistance
Tetraodontiformes - genetics
Transgenic animals
Vertebrates
Xenopus - genetics
Zebrafish - genetics
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Summary:Nobrega et al focuses on scanning human gene deserts for long-range enhancers. The demonstration that several enhancers reside in gene deserts highlights that these regions can indeed serve as reservoirs for sequence elements containing important functions. Observations gathered have implications for studies aiming to decipher the regulatory architecture of the human genome, as well as those exploring the functional impact of sequence variation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1088328