Simultaneous binding of Ptdlns(4,5)P2 adn clathrin by AP180 in the nucleation of clathrin lattices on membranes

Adaptor protein 180 (AP180) and its homolog, clathrin assembly lymphoid myeloid leukemia protein (CALM), are closely related proteins that play important roles in clathrin-mediated endocytosis. Here, we present the structure of the NH2-terminal domain of CALM bound to phosphatidylinositol-4,5-bispho...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2001-02, Vol.291 (5506), p.1051-1055
Main Authors: d, Marijn G J, Pearse, Barbara M F, Higgins, Matthew K, Vallis, Yvonne
Format: Article
Language:English
Subjects:
Cells
Lipids
Literary Devices
Membranes
Molecular biology
Proteins
Online Access:Get full text
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Summary:Adaptor protein 180 (AP180) and its homolog, clathrin assembly lymphoid myeloid leukemia protein (CALM), are closely related proteins that play important roles in clathrin-mediated endocytosis. Here, we present the structure of the NH2-terminal domain of CALM bound to phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2] via a lysine-rich motif.
ISSN:0036-8075
1095-9203