Out of Eden: Stem Cells and Their Niches

Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2000-02, Vol.287 (5457), p.1427-1430
Main Authors: Watt, Fiona M., Brigid L. M. Hogan
Format: Article
Language:English
Subjects:
Adult stem cells
Anatomy
Animals
Blood cells
Cell Communication
Cell Differentiation
Cell Division
Cell Lineage
Cell lines
Cellular biology
Cellular differentiation
Daughter cells
Daughters
Embryonic stem cells
Embryos
Epidermal cells
Extracellular Matrix - physiology
Germ cells
Homeostasis
Humans
Individualized Instruction
Integrins - physiology
Medical research
Pluripotent stem cells
Proteins - physiology
Reviews
Space life sciences
Stem cells
Stem Cells - cytology
Stem Cells - physiology
tissue replacement therapy
Tissues
Transcription Factors - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.287.5457.1427