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The hormone resistin links obesity to diabetes
Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; howe...
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| Published in: | Nature (London) 2001-01, Vol.409 (6818), p.307-312 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c661t-105a42e818fb057808a6f46f16d60c94e6375d697a36fc16fd9729eca070ae0a3 |
| container_end_page | 312 |
| container_issue | 6818 |
| container_start_page | 307 |
| container_title | Nature (London) |
| container_volume | 409 |
| creator | Lazar, Mitchell A Steppan, Claire M Bailey, Shannon T Bhat, Savitha Brown, Elizabeth J Banerjee, Ronadip R Wright, Christopher M Patel, Hiralben R Ahima, Rexford S |
| description | Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes. |
| doi_str_mv | 10.1038/35053000 |
| format | article |
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Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/35053000</identifier><identifier>PMID: 11201732</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>3T3 Cells ; Adipocytes - secretion ; Amino Acid Sequence ; Animals ; Associated diseases and complications ; Base Sequence ; Biological and medical sciences ; Cardiovascular diseases ; Chromosomes, Human, Pair 19 ; Cloning, Molecular ; Diabetes ; diabetes mellitus ; Diabetes Mellitus - blood ; Diabetes Mellitus - etiology ; Diabetes Mellitus - metabolism ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; Diet ; DNA ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epidemics ; Female ; Gene Expression Regulation - drug effects ; Glucose Intolerance ; Hormones ; Hormones - genetics ; Hormones - metabolism ; Hormones - physiology ; Hormones - secretion ; Hormones, Ectopic - genetics ; Hormones, Ectopic - physiology ; Hormones, Ectopic - secretion ; Humanities and Social Sciences ; Humans ; Hypoglycemic Agents - pharmacology ; Insulin Antagonists ; Insulin Resistance ; Intercellular Signaling Peptides and Proteins ; Kidneys ; Male ; Medical research ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; multidisciplinary ; Nerve Growth Factor ; Neutralization ; Neutralization Tests ; Obesity ; Proteins ; Resistin ; Science ; Science (multidisciplinary) ; Signal Transduction ; Thiazoles - pharmacology ; Thiazolidinediones</subject><ispartof>Nature (London), 2001-01, Vol.409 (6818), p.307-312</ispartof><rights>Macmillan Magazines Ltd. 2001</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 Nature Publishing Group</rights><rights>Copyright Macmillan Journals Ltd. Jan 18, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c661t-105a42e818fb057808a6f46f16d60c94e6375d697a36fc16fd9729eca070ae0a3</citedby><cites>FETCH-LOGICAL-c661t-105a42e818fb057808a6f46f16d60c94e6375d697a36fc16fd9729eca070ae0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=851371$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11201732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lazar, Mitchell A</creatorcontrib><creatorcontrib>Steppan, Claire M</creatorcontrib><creatorcontrib>Bailey, Shannon T</creatorcontrib><creatorcontrib>Bhat, Savitha</creatorcontrib><creatorcontrib>Brown, Elizabeth J</creatorcontrib><creatorcontrib>Banerjee, Ronadip R</creatorcontrib><creatorcontrib>Wright, Christopher M</creatorcontrib><creatorcontrib>Patel, Hiralben R</creatorcontrib><creatorcontrib>Ahima, Rexford S</creatorcontrib><title>The hormone resistin links obesity to diabetes</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes.</description><subject>3T3 Cells</subject><subject>Adipocytes - secretion</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Associated diseases and complications</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular diseases</subject><subject>Chromosomes, Human, Pair 19</subject><subject>Cloning, Molecular</subject><subject>Diabetes</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - etiology</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet</subject><subject>DNA</subject><subject>Endocrine pancreas. 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Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>11201732</pmid><doi>10.1038/35053000</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 2001-01, Vol.409 (6818), p.307-312 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743510261 |
| source | Nature Journals Online |
| subjects | 3T3 Cells Adipocytes - secretion Amino Acid Sequence Animals Associated diseases and complications Base Sequence Biological and medical sciences Cardiovascular diseases Chromosomes, Human, Pair 19 Cloning, Molecular Diabetes diabetes mellitus Diabetes Mellitus - blood Diabetes Mellitus - etiology Diabetes Mellitus - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Diet DNA Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemics Female Gene Expression Regulation - drug effects Glucose Intolerance Hormones Hormones - genetics Hormones - metabolism Hormones - physiology Hormones - secretion Hormones, Ectopic - genetics Hormones, Ectopic - physiology Hormones, Ectopic - secretion Humanities and Social Sciences Humans Hypoglycemic Agents - pharmacology Insulin Antagonists Insulin Resistance Intercellular Signaling Peptides and Proteins Kidneys Male Medical research Medical sciences Mice Mice, Inbred C57BL Molecular Sequence Data multidisciplinary Nerve Growth Factor Neutralization Neutralization Tests Obesity Proteins Resistin Science Science (multidisciplinary) Signal Transduction Thiazoles - pharmacology Thiazolidinediones |
| title | The hormone resistin links obesity to diabetes |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T16%3A55%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20hormone%20resistin%20links%20obesity%20to%20diabetes&rft.jtitle=Nature%20(London)&rft.au=Lazar,%20Mitchell%20A&rft.date=2001-01-18&rft.volume=409&rft.issue=6818&rft.spage=307&rft.epage=312&rft.pages=307-312&rft.issn=0028-0836&rft.eissn=1476-4687&rft.coden=NATUAS&rft_id=info:doi/10.1038/35053000&rft_dat=%3Cgale_proqu%3EA188040511%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c661t-105a42e818fb057808a6f46f16d60c94e6375d697a36fc16fd9729eca070ae0a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=204492258&rft_id=info:pmid/11201732&rft_galeid=A188040511&rfr_iscdi=true |