Tail of Integrins, Talin, and Kindlins

Integrins are transmembrane cell-adhesion molecules that carry signals from the outside to the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in response to ligand binding; however, events within the cell can also regulate the affinity of integrins for ligands...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2009-05, Vol.324 (5929), p.895-899
Main Authors: Moser, Markus, Legate, Kyle R, Zent, Roy, Fässler, Reinhard
Format: Article
Language:English
Subjects:
Amino acids
Animals
Binding sites
Biological and medical sciences
Cell Adhesion
Cell adhesion & migration
Cell physiology
Focal adhesions
Fundamental and applied biological sciences. Psychology
Gene expression regulation
Genetic mutation
Humans
Integrins
Integrins - chemistry
Integrins - metabolism
Ligands
Membrane Proteins - chemistry
Membrane Proteins - metabolism
Molecular and cellular biology
Molecular biology
Phosphorylation
Physiological regulation
Platelets
Protein Binding
Protein Conformation
Protein Structure, Tertiary
Proteins
Review
Signal Transduction
Talin - chemistry
Talin - metabolism
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Summary:Integrins are transmembrane cell-adhesion molecules that carry signals from the outside to the inside of the cell and vice versa. Like other cell surface receptors, integrins signal in response to ligand binding; however, events within the cell can also regulate the affinity of integrins for ligands. This feature is important in physiological situations such as those in blood, in which cells are always in close proximity to their ligands, yet cell-ligand interactions occur only after integrin activation in response to specific external cues. This review focuses on the mechanisms whereby two key proteins, talin and the kindlins, regulate integrin activation by binding the tails of integrin-β subunits.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1163865