Temporal Specificity in the Cortical Plasticity of Visual Space Representation

The circuitry and function of mammalian visual cortex are shaped by patterns of visual stimuli, a plasticity likely mediated by synaptic modifications. In the adult cat, asynchronous visual stimuli in two adjacent retinal regions controlled the relative spike timing of two groups of cortical neurons...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2002-06, Vol.296 (5575), p.1999-2003
Main Authors: Fu, Yu-Xi, Djupsund, Kaj, Gao, Hongfeng, Hayden, Benjamin, Shen, Kai, Dan, Yang
Format: Article
Language:English
Subjects:
Action Potentials
Analysis
Animals
Biological and medical sciences
Brain
Brain Mapping
Cats
Conditioning
Conditioning (Psychology)
Correlation
Depression (Psychology)
Eye and associated structures. Visual pathways and centers. Vision
Eyes & eyesight
Feedback (Response)
Fundamental and applied biological sciences. Psychology
Humans
Legends
Neuronal Plasticity
Neurons
Neurons - physiology
Neuroscience
Normal Distribution
Perceptual localization
Photic Stimulation
Pictorial representation
Research Article
Retina - physiology
Space Perception
Spatial Ability
spatial discrimination
Spatial perception
Stimuli
Synapses - physiology
T tests
Time Factors
Vertebrates: nervous system and sense organs
Vision research
Visual cortex
Visual Cortex - physiology
Visual Pathways
Visual perception
Visual stimulation
Visual Stimuli
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Summary:The circuitry and function of mammalian visual cortex are shaped by patterns of visual stimuli, a plasticity likely mediated by synaptic modifications. In the adult cat, asynchronous visual stimuli in two adjacent retinal regions controlled the relative spike timing of two groups of cortical neurons with high precision. This asynchronous pairing induced rapid modifications of intracortical connections and shifts in receptive fields. These changes depended on the temporal order and interval between visual stimuli in a manner consistent with spike timing-dependent synaptic plasticity. Parallel to the cortical modifications found in the cat, such asynchronous visual stimuli also induced shifts in human spatial perception.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1070521