Trifurcate Feed-Forward Regulation of Age-Dependent Cell Death Involving miR164 in Arabidopsis

Aging induces gradual yet massive cell death in higher organisms, including annual plants. Even so, the underlying regulatory mechanisms are barely known, despite the long-standing interest in this topic. Here, we demonstrate that ORE1, which is a NAC (NAM, ATAF, and CUC) transcription factor, posit...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2009-02, Vol.323 (5917), p.1053-1057
Main Authors: Kim, Jin Hee, Woo, Hye Ryun, Kim, Jeongsik, Lim, Pyung Ok, Lee, In Chul, Choi, Seung Hee, Hwang, Daehee, Nam, Hong Gil
Format: Article
Language:English
Subjects:
Age
Aging
Agronomy. Soil science and plant productions
Apoptosis
Arabidopsis - cytology
Arabidopsis - genetics
Arabidopsis - physiology
Arabidopsis Proteins - genetics
Arabidopsis Proteins - physiology
Biological and medical sciences
Botany
Cell cycle
Cell death
Cellular senescence
Chlorophylls
Down regulation
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation, Plant
Genes, Plant
Genetics and breeding of economic plants
Leaves
Messenger RNA
MicroRNAs - genetics
MicroRNAs - physiology
Molecular biology
Mutation
Plant cells
Plant Leaves - cytology
Plant Leaves - physiology
Plants
Plants, Genetically Modified
Receptors, Cell Surface - genetics
Receptors, Cell Surface - physiology
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA, Plant - genetics
RNA, Plant - physiology
Signal Transduction
Transcription factors
Transcription Factors - genetics
Transcription Factors - physiology
Up-Regulation
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Summary:Aging induces gradual yet massive cell death in higher organisms, including annual plants. Even so, the underlying regulatory mechanisms are barely known, despite the long-standing interest in this topic. Here, we demonstrate that ORE1, which is a NAC (NAM, ATAF, and CUC) transcription factor, positively regulates aging-induced cell death in Arabidopsis leaves. ORE1 expression is up-regulated concurrently with leaf aging by EIN2 but is negatively regulated by miR164. miR164 expression gradually decreases with aging through negative regulation by EIN2, which leads to the elaborate up-regulation of ORE1 expression. However, EIN2 still contributes to aging-induced cell death in the absence of ORE1. The trifurcate feed-forward pathway involving ORE1, miR164, and EIN2 provides a highly robust regulation to ensure that aging induces cell death in Arabidopsis leaves.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1166386