Patterns of change in selected serum chemical parameters of middle and later years

Six serum constituents known to vary with renal function were analyzed in a probability sample of 500 persons 55 years and over, and their sex trends compared to other ages. Creatinine, BUN and alkaline phosphatase are elevated in this group whereas calcium is low and phosphorus strikingly so, espec...

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Bibliographic Details
Published in:Journal of gerontology (Kirkwood) 1979-01, Vol.34 (1), p.37-40
Main Authors: Kelly, A, Munan, L, PetitClerc, C, Plante, G, Billon, B
Format: Article
Language:English
Subjects:
Age Factors
Aged
Alkaline Phosphatase - blood
Blood Proteins - analysis
Blood Urea Nitrogen
Calcium - blood
Creatinine - blood
Female
Humans
Male
Middle Aged
Phosphates - blood
Sex Factors
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Summary:Six serum constituents known to vary with renal function were analyzed in a probability sample of 500 persons 55 years and over, and their sex trends compared to other ages. Creatinine, BUN and alkaline phosphatase are elevated in this group whereas calcium is low and phosphorus strikingly so, especially in males. A possible explanation lies in age-related renal parenchymal changes which influence both glomerular filtration and tubular functions in ways that differ from true renal disease. These results have directed implications for geriatric diagnosis and therapy.
ISSN:0022-1422
2331-3323
DOI:10.1093/geronj/34.1.37