Wnt signalling in stem cells and cancer

The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverte...

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Bibliographic Details
Published in:Nature 2005-04, Vol.434 (7035), p.843-850
Main Authors: Clevers, Hans, Reya, Tannishtha
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cancer
Cell division
Cell physiology
Fundamental and applied biological sciences. Psychology
Hematopoietic Stem Cells - metabolism
Hematopoietic Stem Cells - pathology
Humanities and Social Sciences
Humans
Intercellular Signaling Peptides and Proteins - metabolism
Molecular and cellular biology
multidisciplinary
Neoplasms - metabolism
Neoplasms - pathology
Oncology
review-article
Science
Science (multidisciplinary)
Signal Transduction
Stem cells
Stem Cells - metabolism
Stem Cells - pathology
Wnt Proteins
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Summary:The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature03319