Y chromosome of D. pseudoobscura is not homologous to the ancestral Drosophila Y

We report a genome-wide search of Y-linked genes in Drosophila pseudoobscura. All six identifiable orthologs of the D. melanogaster Y-linked genes have autosomal inheritance in D. pseudoobscura. Four orthologs were investigated in detail and proved to be Y-linked in D. guanche and D. bifasciata, whi...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2005-01, Vol.307 (5706), p.108-110
Main Authors: Carvalho, A.B, Clark, A.G
Format: Article
Language:English
Subjects:
Animals
Autosomes
Biological and medical sciences
Biological Evolution
Chromosomes
Chromosomes - genetics
Chromosomes - physiology
Coding
DNA, Intergenic
Drosophila
Drosophila - genetics
Drosophila bifasciata
Drosophila guanche
Drosophila melanogaster
Drosophila melanogaster - genetics
Drosophila pseudoobscura
Evolution
Female
Females
Fundamental and applied biological sciences. Psychology
Genes
Genes, Insect
Genes. Genome
Genetic aspects
Genetic Linkage
Genome
Genomes
Genomics
Insects
Introns
Male
Males
Models, Genetic
Molecular and cellular biology
Molecular genetics
molecular sequence data
nucleotide sequences
Numbers
Phylogeny
Polymerase Chain Reaction
Pseudogenes
Sex chromosomes
Translocation, Genetic
X Chromosome - genetics
X Chromosome - physiology
Y chromosome
Y Chromosome - genetics
Y Chromosome - physiology
Y linked genes
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Summary:We report a genome-wide search of Y-linked genes in Drosophila pseudoobscura. All six identifiable orthologs of the D. melanogaster Y-linked genes have autosomal inheritance in D. pseudoobscura. Four orthologs were investigated in detail and proved to be Y-linked in D. guanche and D. bifasciata, which shows that less than 18 million years ago the ancestral Drosophila Y chromosome was translocated to an autosome in the D. pseudoobscura lineage. We found 15 genes and pseudogenes in the current Y of D. pseudoobscura, and none are shared with the D. melanogaster Y. Hence, the Y chromosome in the D. pseudoobscura lineage appears to have arisen de novo and is not homologous to the D. melanogaster Y.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1101675