Effects of low-power laser irradiation on the threshold of electrically induced paroxysmal discharge in rabbit hippocampus CA1

• Published in: Lasers in medical science 2010-01, Vol.25 (1), p.79-86
• Main Authors: Kogure, Shinichi, Takahashi, Satoshi, Saito, Nobuaki, Kozuka, Kazuya, Matsuda, Yoshiki
• Format: Article
• Language: English
• Subjects: Action Potentials - radiation effects; Animals; Body Temperature; Brain; CA1 Region, Hippocampal - anatomy & histology; CA1 Region, Hippocampal - physiology; CA1 Region, Hippocampal - radiation effects; Clinical outcomes; Convulsions & seizures; Dentistry; Electric Stimulation; Electrophysiological Phenomena; Epilepsy; Epilepsy - physiopathology; Epilepsy - therapy; Lasers; Lasers, Semiconductor - therapeutic use; Low-Level Light Therapy - instrumentation; Low-Level Light Therapy - methods; Male; Medical treatment; Medicine; Medicine & Public Health; Membrane Potentials - radiation effects; Models, Animal; Neural Conduction - radiation effects; Optical Devices; Optics; Original Article; Photonics; Quantum Optics; Rabbits
• ISSN: 0268-8921; 1435-604X
• DOI: 10.1007/s10103-009-0681-4

In acute experiments using adult rabbits, we measured the paroxysmal discharge threshold (PADT) elicited by stimulation to the apical dendritic layer of the hippocampal CA1 region before and after low-power laser irradiation. Nd:YVO 4 laser irradiation (wavelength: 532 nm) was introduced into the same region as the stimulation site. The average PADT was 247 ± 13 μA ( n  = 18) before laser irradiation, while after 5-min laser irradiation with 50, 75, and 100 mW, PADT was 333 ± 40 ( n  = 4), 353 ± 33 ( n  = 4) and 367 ± 27 μA ( n  = 6), respectively. The latter two increments were statistically significant compared to the control ( p