A Prospective Blinded Evaluation of Urinary Porphyrins Verses the Clinical Severity of Autism Spectrum Disorders

A prospective, blinded study evaluated the relationship between autism spectrum disorder (ASD) severity measured by Childhood Autism Rating Scale (CARS) scores and urinary porphyrins among a cohort of participants (n = 26). LabCorp (CLIA-approved) tested for uroporphyrins, heptacarboxylporphyrins, h...

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Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2009-12, Vol.72 (24), p.1585-1591
Main Authors: Geier, David A., Kern, Janet K., Geier, Mark R.
Format: Article
Language:English
Subjects:
Autism
Biomarkers - metabolism
Biomarkers - urine
Cars
Child
Child Development Disorders, Pervasive - physiopathology
Child Development Disorders, Pervasive - urine
Child, Preschool
Correlation
Correlation analysis
Disorders
Female
Heavy metals
Human exposure
Humans
Male
Markers
Mercury
Mercury - metabolism
Mercury - toxicity
Mercury - urine
Metals
Metals, Heavy - metabolism
Metals, Heavy - toxicity
Metals, Heavy - urine
Porphyrins
Porphyrins - classification
Porphyrins - metabolism
Porphyrins - urine
Prospective Studies
Raman scattering
Ratings
Severity of Illness Index
Single-Blind Method
Toxicity
Toxicology
Urinalysis
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Summary:A prospective, blinded study evaluated the relationship between autism spectrum disorder (ASD) severity measured by Childhood Autism Rating Scale (CARS) scores and urinary porphyrins among a cohort of participants (n = 26). LabCorp (CLIA-approved) tested for uroporphyrins, heptacarboxylporphyrins, hexacarboxylporphyrins, pentacarboxylporphyrins, coproporphyrin (cP) I, and cP III levels. Participants with severe ASD had significantly increased cP I, cP III, and total cP levels in comparison to participants with mild ASD. A significant correlation was observed between increasing cP levels and CARS scores. Significant correlations were also noted for comparative urinary porphyrin testing between LabCorp and the Laboratoire Philippe Auguste (ISO-approved) for total cP. Finally, total cP measured at LabCorp was found to significantly correlate with precoproporphryin (a specific porphyrin marker for mercury toxicity) measured at the Laboratoire Philippe Auguste. Since urinary porphyrin testing is clinically available, relatively inexpensive, and noninvasive, it may be used to help suggest whether heavy metal toxicity is associated with ASD.
ISSN:1528-7394
1087-2620
2381-3504
DOI:10.1080/15287390903232475