Bone Marrow as a Potential Source of Hepatic Oval Cells

Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1999-05, Vol.284 (5417), p.1168-1170
Main Authors: Petersen, B. E., Bowen, W. C., Patrene, K. D., Mars, W. M., Sullivan, A. K., Murase, N., Boggs, S. S., Greenberger, J. S., Goff, J. P.
Format: Article
Language:English
Subjects:
2-Acetylaminofluorene - pharmacology
Animals
Biological and medical sciences
Blood cells
Bone marrow
Bone Marrow Cells - cytology
Bone Marrow Transplantation
Carbon Tetrachloride - pharmacology
Cell Differentiation
Cell Division
Cells
Dipeptidyl Peptidase 4 - metabolism
DNA-Binding Proteins - genetics
Donors
Enzymes
Epithelial cells
Epithelial Cells - cytology
Female
Female animals
Females
Fundamental and applied biological sciences. Psychology
Genes
Hematopoietic Stem Cells - cytology
Hepatocytes
In Situ Hybridization
Injuries
Liver
Liver - cytology
Liver - drug effects
Liver - physiology
Liver cells
Liver Regeneration
Liver Transplantation
Liver. Bile. Biliary tracts
Male
Males
Nuclear Proteins
Polymerase Chain Reaction
Rats
Rats, Inbred F344
Rats, Inbred Lew
Regeneration
Rodents
Sex chromosomes
Sex-Determining Region Y Protein
Stem cell transplantation
Stem cells
Stem Cells - cytology
Transcription Factors
Transplantation
Transplants & implants
Vertebrates: digestive system
Y Chromosome
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Description
Summary:Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.284.5417.1168