Copper-Catalyzed One-Pot Synthesis of Substituted Benzimidazoles

A copper‐catalyzed one‐pot synthesis of functionalized benzimidazoles has been developed. The procedure combines the copper‐catalyzed three‐component cascade reaction of sulfonyl azides, alkynes and 2‐bromoaniline and the copper‐catalyzed intramolecular N‐arylation of sulfonamides in one sequence, w...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2010-02, Vol.352 (2-3), p.347-350
Main Authors: Jin, Hongwei, Xu, Xiaoliang, Gao, Jianrong, Zhong, Jianhua, Wang, Yanguang
Format: Article
Language:English
Subjects:
arylation
benzimidazoles
cascade reactions
copper catalysts
multicomponent reactions
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Summary:A copper‐catalyzed one‐pot synthesis of functionalized benzimidazoles has been developed. The procedure combines the copper‐catalyzed three‐component cascade reaction of sulfonyl azides, alkynes and 2‐bromoaniline and the copper‐catalyzed intramolecular N‐arylation of sulfonamides in one sequence, which afforded the products in moderate to good yields.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200900706