Dirty Transcripts from Clean DNA

A. Viswanathan et al have demonstrated that a miscoding base in DNA can give rise to an altered mRNA transcript and a mutant protein in vivo in nondividing bacteria and in nondividing mammalian cells.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1999-04, Vol.284 (5411), p.62-63
Main Author: Bridges, Bryn A.
Format: Article
Language:English
Subjects:
Alzheimers Disease
Animals
Bacteria
Base Pair Mismatch
Biological and medical sciences
Cells
Coding
Deoxyribonucleic acid
DNA
DNA Damage
DNA Repair
DNA, Bacterial - genetics
Escherichia coli
Escherichia coli - genetics
Evidence
Fundamental and applied biological sciences. Psychology
Genes
Genetic mutation
Humans
Messenger RNA
Molecular and cellular biology
Molecular genetics
Mutagenesis
Mutation
Neurons
Neurons - metabolism
Perspectives
Phenotype
Proteins
Rats
Rats, Brattleboro
Reverse transcriptase
Ribonucleic acid
RNA
RNA, Bacterial - genetics
RNA, Messenger - genetics
Sequence Deletion
Stop codon
Templates, Genetic
Transcription, Genetic
Transcription. Transcription factor. Splicing. Rna processing
Transcripts (Written Records)
Uracil - metabolism
Vasopressins - genetics
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Items that cite this one
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Description
Summary:A. Viswanathan et al have demonstrated that a miscoding base in DNA can give rise to an altered mRNA transcript and a mutant protein in vivo in nondividing bacteria and in nondividing mammalian cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.284.5411.62