GAD, a Single Autoantigen for Diabetes

Type I diabetes is an autoimmune disease that affects 0.3% of the world's population. A breakthrough in understanding the etiology of type I diabetes is discussed.

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1999-05, Vol.284 (5417), p.1135-1137
Main Authors: von Boehmer, Harald, Sarukhan, Adelaida
Format: Article
Language:English
Subjects:
Animals
Antigen presenting cells
Autoantigens
Autoantigens - genetics
Autoantigens - immunology
Autoantigens - physiology
Autoimmune diseases
Biological and medical sciences
Causes of
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - enzymology
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - therapy
Diabetes. Impaired glucose tolerance
DNA, Antisense
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glutamate decarboxylase
Glutamate Decarboxylase - genetics
Glutamate Decarboxylase - immunology
Glutamate Decarboxylase - physiology
Humans
Immunity (Disease)
Insulin
Islet cells
Islets of Langerhans - enzymology
Islets of Langerhans - immunology
Lymphocyte Activation
Medical research
Medical sciences
Mice
Mice, Inbred NOD
Mice, Transgenic
Patients
Peptides
Perspectives
Physiological aspects
Rodents
Self Tolerance
T lymphocytes
T-Lymphocytes - immunology
Transgenes
Type 1 diabetes
Type 1 diabetes mellitus
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Description
Summary:Type I diabetes is an autoimmune disease that affects 0.3% of the world's population. A breakthrough in understanding the etiology of type I diabetes is discussed.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.284.5417.1135