Altered Nociceptive Neuronal Circuits after Neonatal Peripheral Inflammation

Nociceptive neuronal circuits are formed during embryonic and postnatal times when painful stimuli are normally absent or limited. Today, medical procedures for neonates with health risks can involve tissue injury and pain for which the long-term effects are unknown. To investigate the impact of neo...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2000-07, Vol.289 (5479), p.628-630
Main Authors: Ruda, M. A., Ling, Qing-Dong, Hohmann, Andrea G., Peng, Yuan Bo, Tachibana, Toshiya
Format: Article
Language:English
Subjects:
Adults
Afferent Pathways
Anatomy
Animals
Animals, Newborn
Axons
Axons - physiology
Biological and medical sciences
Cell Count
Density
Development
Developmental neurology
Feedback (Response)
Freund's Adjuvant
Fundamental and applied biological sciences. Psychology
Ganglia, Spinal - cytology
Ganglia, Spinal - physiology
Hindlimb - innervation
Infant development
Infants
Infants (Newborn)
Inflammation
Inflammation - physiopathology
Injuries
Male
Neonates
Nervous system
Neurons
Neurons, Afferent - cytology
Neurons, Afferent - physiology
Newborn infants
Nociceptive pain
Nociceptors
Pain
Pain Measurement
Pain Threshold
Physical trauma
Posterior Horn Cells - cytology
Posterior Horn Cells - physiology
Pups
Rats
Rats, Sprague-Dawley
Sciatic nerve
Sciatic Nerve - cytology
Sciatic Nerve - physiology
Sensory receptors
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Spinal cord
Stimulation
Stimuli
Tissues
Vertebrates: nervous system and sense organs
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
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Summary:Nociceptive neuronal circuits are formed during embryonic and postnatal times when painful stimuli are normally absent or limited. Today, medical procedures for neonates with health risks can involve tissue injury and pain for which the long-term effects are unknown. To investigate the impact of neonatal tissue injury and pain on development of nociceptive neuronal circuitry, we used an animal model of persistent hind paw peripheral inflammation. We found that, as adults, these animals exhibited spinal neuronal circuits with increased input and segmental changes in nociceptive primary afferent axons and altered responses to sensory stimulation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.289.5479.628