Multilineage Potential of Adult Human Mesenchymal Stem Cells

Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1999-04, Vol.284 (5411), p.143-147
Main Authors: Pittenger, Mark F., Mackay, Alastair M., Beck, Stephen C., Jaiswal, Rama K., Douglas, Robin, Mosca, Joseph D., Moorman, Mark A., Simonetti, Donald W., Craig, Stewart, Marshak, Daniel R.
Format: Article
Language:English
Subjects:
Adipocytes
Adipocytes - cytology
Adult
Adult stem cells
Adults
Apoptosis
Biological and medical sciences
Bone marrow
Bone marrow cells
Bone Marrow Cells - cytology
Cell Differentiation
Cell differentiation, maturation, development, hematopoiesis
Cell Division
Cell Lineage
Cell physiology
Cell Separation
Cells
Cells, Cultured
Cellular biology
Cellular differentiation
Chondrocytes
Chondrocytes - cytology
Cultured cells
Donors
Fibroblasts - cytology
Flow Cytometry
Fundamental and applied biological sciences. Psychology
Humans
Individualized Instruction
Logical Thinking
Mesenchymal stem cells
Mesoderm - cytology
Middle Aged
Molecular and cellular biology
Multipotent stem cells
Osteocytes - cytology
Phenotype
Pluripotent stem cells
Selection Criteria
Stem cells
Stem Cells - cytology
Tissues
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Description
Summary:Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.284.5411.143