Nonblinking and Nonbleaching Upconverting Nanoparticles as an Optical Imaging Nanoprobe and T1 Magnetic Resonance Imaging Contrast Agent

Core/shell upconverting nanoparticles (UCNPs) of NaGdF4:Er3+,Yb3+/NaGdF4 (see figure) are shown to serve as a multimodal imaging probe that works for both background‐free optical imaging and magnetic resonance imaging (MRI). The nonblinking and nonbleaching properties of UCNPs can contribute to mini...

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Published in:Advanced materials (Weinheim) 2009-11, Vol.21 (44), p.4467-4471
Main Authors: Park, Yong Il, Kim, Jeong Hyun, Lee, Kang Taek, Jeon, Ki-Seok, Na, Hyon Bin, Yu, Jung Ho, Kim, Hyung Min, Lee, Nohyun, Choi, Seung Hong, Baik, Sung-Il, Kim, Hyoungsu, Park, Seung Pyo, Park, Beom-Jin, Kim, Young Woon, Lee, Sung Ho, Yoon, Soo-Young, Song, In Chan, Moon, Woo Kyung, Suh, Yung Doug, Hyeon, Taeghwan
Format: Article
Language:English
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Summary:Core/shell upconverting nanoparticles (UCNPs) of NaGdF4:Er3+,Yb3+/NaGdF4 (see figure) are shown to serve as a multimodal imaging probe that works for both background‐free optical imaging and magnetic resonance imaging (MRI). The nonblinking and nonbleaching properties of UCNPs can contribute to minimization of possible artifacts in long‐term imaging experiments. Owing to Gd3+ ions in the host matrix, contrast is enhanced in T1‐weighted MRI.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200901356