Organogenic Role of B Lymphocytes in Mucosal Immunity

Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immuno...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1999-12, Vol.286 (5446), p.1965-1968
Main Authors: Golovkina, Tatyana V., Shlomchik, Mark, Hannum, Lynn, Chervonsky, Alexander
Format: Article
Language:English
Subjects:
Animals
B cells
B lymphocytes
B-Lymphocytes - immunology
Biological and medical sciences
Cell Count
Cell lines
Cellular biology
Epithelial cells
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Genes, Immunoglobulin
Immune system
Immunity
Immunity (Physiology)
Immunity, Mucosal
Immunobiology
Immunoglobulin M - genetics
Immunoglobulin M - immunology
Infections
Lymphocyte Activation
Lymphoid organs: ontogeny, organization, homing phenomenon
Mammary Tumor Virus, Mouse - physiology
Medical research
Mice
Mice, Inbred Strains
Mice, Knockout
Mice, Transgenic
Microscopy, Electron, Scanning
Mucosal immunity
Mucous membrane
Numbers
Pathogens
Peyer's Patches - cytology
Peyer's Patches - immunology
Peyer's Patches - ultrastructure
Peyers patches
Physiological aspects
Retroviridae Infections - immunology
Retroviridae Infections - virology
Rodents
Scientific Concepts
T lymphocytes
T-Lymphocytes - immunology
Transgenic animals
Tumor Virus Infections - immunology
Tumor Virus Infections - virology
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Summary:Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.286.5446.1965