Room Temperature Lewis Base-Catalyzed Alumination of Terminal Alkynes

An efficient and mild access to mixed dimethylalkynylaluminum reagents has been developed via a direct Lewis base‐catalyzed alumination of terminal alkynes by trimethylaluminum. The use of bis(trimethylsilyl)methylamine enables the metalation at room temperature with only 1% of catalyst loading.

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2009-11, Vol.351 (16), p.2595-2598
Main Authors: Zhou, Yuhan, Lecourt, Thomas, Micouin, Laurent
Format: Article
Language:English
Subjects:
acetylides
alanes
alkynes
Lewis base catalysis
organoaluminum reagents
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Description
Summary:An efficient and mild access to mixed dimethylalkynylaluminum reagents has been developed via a direct Lewis base‐catalyzed alumination of terminal alkynes by trimethylaluminum. The use of bis(trimethylsilyl)methylamine enables the metalation at room temperature with only 1% of catalyst loading.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200900414