Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa

Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA). Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with spe...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1999-11, Vol.286 (5444), p.1561-1565
Main Authors: Ernst, Robert K., Yi, Eugene C., Guo, Lin, Lim, Kheng B., Burns, Jane L., Hackett, Murray, Miller, Samuel I.
Format: Article
Language:English
Subjects:
Acylation
Amino compounds
Arabinose - analogs & derivatives
Arabinose - analysis
Arabinose - metabolism
Bacterial diseases
Bacterial diseases of the respiratory system
Bacterial Proteins - genetics
Bacterial Proteins - physiology
Biological and medical sciences
Blood
Bronchiectasis
Cell growth
Cells, Cultured
Cystic fibrosis
Cystic Fibrosis - complications
Cystic Fibrosis - microbiology
Drug Resistance, Microbial
Fatty acids
Human bacterial diseases
Humans
Infant
Infections
Infectious diseases
Interleukin-8 - biosynthesis
Laboratories
Lipid A - biosynthesis
Lipid A - chemistry
Lipids
Lipopolysaccharides - chemistry
Lipopolysaccharides - immunology
Magnesium
Magnesium - pharmacology
Mass spectroscopy
Medical research
Medical sciences
Mutation
Palmitates
Palmitates - analysis
Palmitates - metabolism
Patients
Peptides - pharmacology
Polymyxins
Polymyxins - pharmacology
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - genetics
Pseudomonas aeruginosa - metabolism
Pseudomonas aeruginosa - pathogenicity
Pseudomonas Infections - microbiology
Respiratory System - microbiology
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Virulence
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Description
Summary:Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA). Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.286.5444.1561