Synexpression groups in eukaryotes

In 1960, Jacob and Monod described the bacterial operon, a cluster of functionally interacting genes whose expression is tightly coordinated. Global expression analysis has shown that the highly coordinate expression of genes functioning in common processes is also a widespread phenomenon in eukaryo...

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Bibliographic Details
Published in:Nature (London) 1999-12, Vol.402 (6761), p.483-487
Main Authors: Niehrs, Christof, Pollet, Nicolas
Format: Article
Language:English
Subjects:
Animals
Bacteria
Biological and medical sciences
Cholesterol - biosynthesis
Cholesterol - genetics
Eukaryotic Cells - metabolism
Evolution
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation
Genes
Genetics
Humanities and Social Sciences
Humans
Molecular and cellular biology
Molecular biology
Molecular genetics
multidisciplinary
Oligonucleotide Array Sequence Analysis
Operon
progress
Science
Science (multidisciplinary)
Space life sciences
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Summary:In 1960, Jacob and Monod described the bacterial operon, a cluster of functionally interacting genes whose expression is tightly coordinated. Global expression analysis has shown that the highly coordinate expression of genes functioning in common processes is also a widespread phenomenon in eukaryotes. These sets of co-regulated genes, or ‘synexpression groups’, show a striking parallel to the operon, and may be a key determinant facilitating evolutionary change leading to animal diversity.
ISSN:0028-0836
1476-4687
DOI:10.1038/990025