Zinc Fingers in Caenorhabditis elegans: Finding Families and Probing Pathways

More than 3 percent of the protein sequences inferred from the Caenorhabditis elegans genome contain sequence motifs characteristic of zinc-binding structural domains, and of these more than half are believed to be sequence-specific DNA-binding proteins. The distribution of these zinc-binding domain...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1998-12, Vol.282 (5396), p.2018-2022
Main Authors: Clarke, Neil D., Berg, Jeremy M.
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Caenorhabditis elegans
Caenorhabditis elegans - chemistry
Caenorhabditis elegans - genetics
Caenorhabditis elegans - metabolism
Caenorhabditis elegans Proteins
Coding
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Evolution
Evolution, Molecular
GATA Transcription Factors
Gene Expression Regulation
Genes
Genetic aspects
Genetic regulation
Genetic transcription
Genomes
Helminth Proteins - chemistry
Helminth Proteins - genetics
Helminth Proteins - metabolism
Hormone receptors
Literary Devices
Membrane Proteins - chemistry
Membrane Proteins - genetics
Membrane Proteins - metabolism
Open reading frames
Proteins
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - genetics
Regulation
Reviews
Sex Education
Statistical distributions
Trans-Activators - chemistry
Trans-Activators - genetics
Trans-Activators - metabolism
Transcription (Genetics)
Transcription Factors - chemistry
Transcription Factors - genetics
Transcription Factors - metabolism
Worms
Yeasts
Zinc
Zinc Fingers
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Description
Summary:More than 3 percent of the protein sequences inferred from the Caenorhabditis elegans genome contain sequence motifs characteristic of zinc-binding structural domains, and of these more than half are believed to be sequence-specific DNA-binding proteins. The distribution of these zinc-binding domains among the genomes of various organisms offers insights into the role of zinc-binding proteins in evolution. In addition, the complete genome sequence of C. elegans provides an opportunity to analyze, and perhaps predict, pathways of transcriptional regulation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.282.5396.2018