The influence of pre- and perinatal malnutrition on sulphated glycosaminoglycans in rat brain

Pre- and perinatal malnutrition of rats was achieved by restricting the intake of food to 50% during lactation and pregnancy. After 40 days offspring were injected with Na2(35)SO4 before being killed. Lipid-free brain material was now hydrolysed with papain and glycosaminoglycan samples chromatograp...

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Bibliographic Details
Published in:Research in experimental medicine 1979-06, Vol.174 (2), p.153-158
Main Authors: White, C J, Appleby, J A
Format: Article
Language:English
Subjects:
Animals
Brain - embryology
Brain - growth & development
Brain - metabolism
Chondroitin Sulfates - metabolism
Female
Glycosaminoglycans - metabolism
Heparitin Sulfate - metabolism
Nutrition Disorders - metabolism
Pregnancy
Pregnancy Complications - metabolism
Rats
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Summary:Pre- and perinatal malnutrition of rats was achieved by restricting the intake of food to 50% during lactation and pregnancy. After 40 days offspring were injected with Na2(35)SO4 before being killed. Lipid-free brain material was now hydrolysed with papain and glycosaminoglycan samples chromatographed on DEAE-cellulose. After chemical characterisation studies 2.5 times more chondroitin sulphate was detected in tissue from the ill-fed animals. Little variation in heparan sulphate content was observed. The marked increase in the concentration as well as qualitative changes in sulphated glycosaminoglycans during pre- and perinatal malnutrition as compared to the normal are discussed in relation to brain maturation.
ISSN:0300-9130
1433-8580
DOI:10.1007/BF01851327