Transfer of Experimental Allergic Encephalomyelitis with Guinea Pig Peritoneal Exudate Cells

Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 10$^{7}$ cells. With this relatively small number of cells, in vitro st...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1979-02, Vol.203 (4380), p.547-548
Main Authors: Driscoll, Bernard F., Kies, Marian W., Alvord, Ellsworth C.
Format: Article
Language:English
Subjects:
Animals
Antigens
Ascitic Fluid - cytology
Ascitic Fluid - immunology
Cell Adhesion
Cell Division
Cultured cells
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - transmission
Experimental autoimmune encephalomyelitis
Exudates and Transudates - immunology
Guinea Pigs
Histology
Immunization, Passive
Male
Myelin Basic Protein - immunology
Myelin basic proteins
Phagocytes
Sensitization
Spleen cells
Tissue culture techniques
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Summary:Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 10$^{7}$ cells. With this relatively small number of cells, in vitro studies to determine the immunologic mechanisms involved in the disease process are now possible.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.83676