Transfer of Experimental Allergic Encephalomyelitis with Guinea Pig Peritoneal Exudate Cells

Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 10$^{7}$ cells. With this relatively small number of cells, in vitro st...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1979-02, Vol.203 (4380), p.547-548
Main Authors: Driscoll, Bernard F., Kies, Marian W., Alvord, Ellsworth C.
Format: Article
Language:English
Subjects:
Animals
Antigens
Ascitic Fluid - cytology
Ascitic Fluid - immunology
Cell Adhesion
Cell Division
Cultured cells
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - transmission
Experimental autoimmune encephalomyelitis
Exudates and Transudates - immunology
Guinea Pigs
Histology
Immunization, Passive
Male
Myelin Basic Protein - immunology
Myelin basic proteins
Phagocytes
Sensitization
Spleen cells
Tissue culture techniques
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c337t-1e01a27de8f981c6f25c2d2850d0d188994c4d76d0b918327209b19ea0b8b5043
cites cdi_FETCH-LOGICAL-c337t-1e01a27de8f981c6f25c2d2850d0d188994c4d76d0b918327209b19ea0b8b5043
container_end_page 548
container_issue 4380
container_start_page 547
container_title Science (American Association for the Advancement of Science)
container_volume 203
creator Driscoll, Bernard F.
Kies, Marian W.
Alvord, Ellsworth C.
description Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 10$^{7}$ cells. With this relatively small number of cells, in vitro studies to determine the immunologic mechanisms involved in the disease process are now possible.
doi_str_mv 10.1126/science.83676
format article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_74432042</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>1747176</jstor_id><sourcerecordid>1747176</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-1e01a27de8f981c6f25c2d2850d0d188994c4d76d0b918327209b19ea0b8b5043</originalsourceid><addsrcrecordid>eNpFkD1PwzAQhi0EglIYmWDwxBY420lsj6gqHxISHWBDihznAkZuUuxE0H-PoQWmk_U-fnT3EnLC4IIxXl5G67CzeKFEKcsdMmGgi0xzELtkAiDKTIEsDshhjG8AKdNin-z9wBPy_BhMF1sMtG_p_HOFwS2xG4ynV95jeHGWzpN79Wp8v1yjd4OL9MMNr_RmdB0aunAvdJF-DX16-aQYGzMgnaH38YjstcZHPN7OKXm6nj_ObrP7h5u72dV9ZoWQQ8YQmOGyQdVqxWzZ8sLyhqsCGmiYUlrnNm9k2UCtmRJcctA102igVnUBuZiS8413Ffr3EeNQLV20aQPTYT_GSua54JDzBGYb0IY-xoBttUr3mrCuGFTfXVbbLqufehJ_uhWP9RKbP_o3Pdukb3How79K5pKl-AtjZnpJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74432042</pqid></control><display><type>article</type><title>Transfer of Experimental Allergic Encephalomyelitis with Guinea Pig Peritoneal Exudate Cells</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>Science Online_科学在线</source><creator>Driscoll, Bernard F. ; Kies, Marian W. ; Alvord, Ellsworth C.</creator><creatorcontrib>Driscoll, Bernard F. ; Kies, Marian W. ; Alvord, Ellsworth C.</creatorcontrib><description>Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 10$^{7}$ cells. With this relatively small number of cells, in vitro studies to determine the immunologic mechanisms involved in the disease process are now possible.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.83676</identifier><identifier>PMID: 83676</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Antigens ; Ascitic Fluid - cytology ; Ascitic Fluid - immunology ; Cell Adhesion ; Cell Division ; Cultured cells ; Encephalomyelitis, Autoimmune, Experimental - immunology ; Encephalomyelitis, Autoimmune, Experimental - transmission ; Experimental autoimmune encephalomyelitis ; Exudates and Transudates - immunology ; Guinea Pigs ; Histology ; Immunization, Passive ; Male ; Myelin Basic Protein - immunology ; Myelin basic proteins ; Phagocytes ; Sensitization ; Spleen cells ; Tissue culture techniques</subject><ispartof>Science (American Association for the Advancement of Science), 1979-02, Vol.203 (4380), p.547-548</ispartof><rights>Copyright 1979 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-1e01a27de8f981c6f25c2d2850d0d188994c4d76d0b918327209b19ea0b8b5043</citedby><cites>FETCH-LOGICAL-c337t-1e01a27de8f981c6f25c2d2850d0d188994c4d76d0b918327209b19ea0b8b5043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1747176$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1747176$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,2884,2885,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/83676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Driscoll, Bernard F.</creatorcontrib><creatorcontrib>Kies, Marian W.</creatorcontrib><creatorcontrib>Alvord, Ellsworth C.</creatorcontrib><title>Transfer of Experimental Allergic Encephalomyelitis with Guinea Pig Peritoneal Exudate Cells</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 10$^{7}$ cells. With this relatively small number of cells, in vitro studies to determine the immunologic mechanisms involved in the disease process are now possible.</description><subject>Animals</subject><subject>Antigens</subject><subject>Ascitic Fluid - cytology</subject><subject>Ascitic Fluid - immunology</subject><subject>Cell Adhesion</subject><subject>Cell Division</subject><subject>Cultured cells</subject><subject>Encephalomyelitis, Autoimmune, Experimental - immunology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - transmission</subject><subject>Experimental autoimmune encephalomyelitis</subject><subject>Exudates and Transudates - immunology</subject><subject>Guinea Pigs</subject><subject>Histology</subject><subject>Immunization, Passive</subject><subject>Male</subject><subject>Myelin Basic Protein - immunology</subject><subject>Myelin basic proteins</subject><subject>Phagocytes</subject><subject>Sensitization</subject><subject>Spleen cells</subject><subject>Tissue culture techniques</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><recordid>eNpFkD1PwzAQhi0EglIYmWDwxBY420lsj6gqHxISHWBDihznAkZuUuxE0H-PoQWmk_U-fnT3EnLC4IIxXl5G67CzeKFEKcsdMmGgi0xzELtkAiDKTIEsDshhjG8AKdNin-z9wBPy_BhMF1sMtG_p_HOFwS2xG4ynV95jeHGWzpN79Wp8v1yjd4OL9MMNr_RmdB0aunAvdJF-DX16-aQYGzMgnaH38YjstcZHPN7OKXm6nj_ObrP7h5u72dV9ZoWQQ8YQmOGyQdVqxWzZ8sLyhqsCGmiYUlrnNm9k2UCtmRJcctA102igVnUBuZiS8413Ffr3EeNQLV20aQPTYT_GSua54JDzBGYb0IY-xoBttUr3mrCuGFTfXVbbLqufehJ_uhWP9RKbP_o3Pdukb3How79K5pKl-AtjZnpJ</recordid><startdate>19790209</startdate><enddate>19790209</enddate><creator>Driscoll, Bernard F.</creator><creator>Kies, Marian W.</creator><creator>Alvord, Ellsworth C.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790209</creationdate><title>Transfer of Experimental Allergic Encephalomyelitis with Guinea Pig Peritoneal Exudate Cells</title><author>Driscoll, Bernard F. ; Kies, Marian W. ; Alvord, Ellsworth C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-1e01a27de8f981c6f25c2d2850d0d188994c4d76d0b918327209b19ea0b8b5043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Ascitic Fluid - cytology</topic><topic>Ascitic Fluid - immunology</topic><topic>Cell Adhesion</topic><topic>Cell Division</topic><topic>Cultured cells</topic><topic>Encephalomyelitis, Autoimmune, Experimental - immunology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - transmission</topic><topic>Experimental autoimmune encephalomyelitis</topic><topic>Exudates and Transudates - immunology</topic><topic>Guinea Pigs</topic><topic>Histology</topic><topic>Immunization, Passive</topic><topic>Male</topic><topic>Myelin Basic Protein - immunology</topic><topic>Myelin basic proteins</topic><topic>Phagocytes</topic><topic>Sensitization</topic><topic>Spleen cells</topic><topic>Tissue culture techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Driscoll, Bernard F.</creatorcontrib><creatorcontrib>Kies, Marian W.</creatorcontrib><creatorcontrib>Alvord, Ellsworth C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Driscoll, Bernard F.</au><au>Kies, Marian W.</au><au>Alvord, Ellsworth C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transfer of Experimental Allergic Encephalomyelitis with Guinea Pig Peritoneal Exudate Cells</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1979-02-09</date><risdate>1979</risdate><volume>203</volume><issue>4380</issue><spage>547</spage><epage>548</epage><pages>547-548</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Incubation with specific antigen, myelin basic protein, greatly enhances the ability of guinea pig peritoneal exudate cells to transfer experimental allergic encephalomyelitis. Reproducibly successful transfers are obtained with 10$^{7}$ cells. With this relatively small number of cells, in vitro studies to determine the immunologic mechanisms involved in the disease process are now possible.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>83676</pmid><doi>10.1126/science.83676</doi><tpages>2</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1979-02, Vol.203 (4380), p.547-548
issn 0036-8075
1095-9203
language eng
recordid cdi_proquest_miscellaneous_74432042
source JSTOR Archival Journals and Primary Sources Collection; Science Online_科学在线
subjects Animals
Antigens
Ascitic Fluid - cytology
Ascitic Fluid - immunology
Cell Adhesion
Cell Division
Cultured cells
Encephalomyelitis, Autoimmune, Experimental - immunology
Encephalomyelitis, Autoimmune, Experimental - transmission
Experimental autoimmune encephalomyelitis
Exudates and Transudates - immunology
Guinea Pigs
Histology
Immunization, Passive
Male
Myelin Basic Protein - immunology
Myelin basic proteins
Phagocytes
Sensitization
Spleen cells
Tissue culture techniques
title Transfer of Experimental Allergic Encephalomyelitis with Guinea Pig Peritoneal Exudate Cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T07%3A49%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Transfer%20of%20Experimental%20Allergic%20Encephalomyelitis%20with%20Guinea%20Pig%20Peritoneal%20Exudate%20Cells&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Driscoll,%20Bernard%20F.&rft.date=1979-02-09&rft.volume=203&rft.issue=4380&rft.spage=547&rft.epage=548&rft.pages=547-548&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.83676&rft_dat=%3Cjstor_proqu%3E1747176%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c337t-1e01a27de8f981c6f25c2d2850d0d188994c4d76d0b918327209b19ea0b8b5043%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=74432042&rft_id=info:pmid/83676&rft_jstor_id=1747176&rfr_iscdi=true