Theophylline Protein Binding in Humans

Theophylline protein binding was 58–82% in serum from six normal adults and 42 asthmatic patients, 1–25 years old, who were given 5mg of theophylline/kg. The binding range was greatest in young patients, but the proportion of protein-bound drug did not correlate with age. Theophylline protein bindin...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1979-02, Vol.68 (2), p.252-253
Main Authors: Simons, K.J., Simons, F.E.R., Briggs, C.J., Lo, L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Asthma - blood
Blood Proteins - metabolism
Child
Child, Preschool
Humans
Infant
Protein Binding
protein binding in humans
Protein binding-theophylline in humans
Relaxants
Relaxants smooth muscle—theophylline, protein binding in humans
smooth muscle-theophylline
Theophylline - blood
Theophylline-protein binding in humans
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Summary:Theophylline protein binding was 58–82% in serum from six normal adults and 42 asthmatic patients, 1–25 years old, who were given 5mg of theophylline/kg. The binding range was greatest in young patients, but the proportion of protein-bound drug did not correlate with age. Theophylline protein binding was higher than previously reported. The effect of binding should be considered in patients who do not have optimal bronchodilation from theophylline despite total serum theophylline concentrations of 10–20μg/ml.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600680238