functional state of the serotonergic system and the 5-HTTLPR polymorphism of the serotonin transporter gene in patients with schizophrenia

Blood serotonin concentration is implicated in the regulation of behavior as well as in the development of psychopathological symptoms. Serotonin transporter regulates the serotonin level by reuptaking it from the synaptic cleft. In this study, platelet serotonin concentrations and the serotonin bin...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology (New York) 2010-04, Vol.44 (2), p.223-227
Main Authors: Golimbet, V. E, Korovaitseva, G. I, Brusov, O. S, Faktor, M. I, Ganisheva, T. K, Dmitriev, D. A
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Genomics. Transcriptomics
Genotype & phenotype
Human Genetics
Life Sciences
Molecular biology
Polymorphism
Psychopathology
Schizophrenia
Serotonin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Blood serotonin concentration is implicated in the regulation of behavior as well as in the development of psychopathological symptoms. Serotonin transporter regulates the serotonin level by reuptaking it from the synaptic cleft. In this study, platelet serotonin concentrations and the serotonin binding constant (V max) were compared in patients with schizophrenia and healthy individuals with different 5-HTTLPR genotypes. The study included 60 patients and 62 controls. The above biochemical parameters were associated with the 5-HTTLPR genotype. Both in patients and controls, carriers of the LL genotype had lower blood serotonin concentrations and V max as compared to those with genotypes containing one or two S alleles. These results suggest that the 5-HTTLPR polymorphism of the serotonin transporter gene is involved in regulating the state of the serotonergic system.
ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893310020068