Risk-reducing mastectomy and salpingo-oophorectomy in unaffected BRCA mutation carriers: uptake and timing

Skytte A‐B, Gerdes A‐M, Andersen MK, Sunde L, Brøndum‐Nielsen K, Waldstrøm M, Kølvraa S, Crüger D. Risk‐reducing mastectomy and salpingo‐oophorectomy in unaffected BRCA mutation carriers: uptake and timing. Once female carriers of a BRCA mutation are identified they have to make decisions on risk ma...

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Bibliographic Details
Published in:Clinical genetics 2010-04, Vol.77 (4), p.342-349
Main Authors: Skytte, A-B, Gerdes, A-M, Andersen, MK, Sunde, L, Brøndum-Nielsen, K, Waldstrøm, M, Kølvraa, S, Crüger, D
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Biological and medical sciences
BRCA1
BRCA1 Protein - genetics
BRCA2
BRCA2 Protein - genetics
Breast cancer
Data processing
Decision making
Fallopian Tubes - surgery
Female
Fundamental and applied biological sciences. Psychology
General aspects. Genetic counseling
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Heterozygote
Humans
Mastectomy
Mastectomy - methods
Medical genetics
Medical sciences
Middle Aged
Molecular and cellular biology
Mutation
Mutation - genetics
Ovariectomy - methods
Risk assessment
Risk Factors
risk reducing
salpingo oophorectomy
Surgery
Time Factors
Womens health
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Summary:Skytte A‐B, Gerdes A‐M, Andersen MK, Sunde L, Brøndum‐Nielsen K, Waldstrøm M, Kølvraa S, Crüger D. Risk‐reducing mastectomy and salpingo‐oophorectomy in unaffected BRCA mutation carriers: uptake and timing. Once female carriers of a BRCA mutation are identified they have to make decisions on risk management. The aim of this study is to outline the uptake of risk‐reducing surgery in the Danish population of BRCA mutation positive women and to search for factors affecting this decision. We analysed data from 306 healthy BRCA carriers with no personal history of ovarian or breast cancer. We found a 10‐year uptake of 75% for risk‐reducing salpingo‐oophorectomy and 50% for risk‐reducing mastectomy by time to event analysis. Age and childbirth influenced this decision. The uptake rate has not changed significantly over the last decade. Risk‐reducing surgeries are widely acceptable among Danish BRCA mutation positive women and the uptake of prophylactic mastectomy is higher than in most other countries.
ISSN:0009-9163
1399-0004
DOI:10.1111/j.1399-0004.2009.01329.x