Novel strategies for the treatment of inflammatory hyperalgesia

There is a large unmet medical need in the area of treatment of inflammatory pain initiated by tissue damage or inflammation that manifests as spontaneous pain and pain hypersensitivity (hyperalgesia).The current review focuses on the key mechanisms that produce hyperalgesia that accompanies inflamm...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical pharmacology 2010-05, Vol.66 (5), p.429-444
Main Authors: Chopade, Atul R, Mulla, Wahid A
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Analgesics - therapeutic use
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Biomedical and Life Sciences
Biomedicine
Drug Delivery Systems - methods
Humans
Hyperalgesia - drug therapy
Hyperalgesia - metabolism
Inflammation - complications
Inflammation - drug therapy
Inflammation Mediators - metabolism
Inflammatory diseases
Neurons, Afferent - drug effects
Pain management
Pharmacology
Pharmacology/Toxicology
Review Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There is a large unmet medical need in the area of treatment of inflammatory pain initiated by tissue damage or inflammation that manifests as spontaneous pain and pain hypersensitivity (hyperalgesia).The current review focuses on the key mechanisms that produce hyperalgesia that accompanies inflammation. Also, the inflammatory mediators that interact with neurons to produce hyperalgesia are explored. As the dominant classes of analgesic drugs such as the NSAIDs and the opiates are limited by their side effects and tolerability, elucidation of the molecular mechanisms responsible for inflammatory pain provides novel opportunities for therapeutic approaches for managing inflammatory pain, with improved specificity, efficacy, and possibly with fewer toxic effects.
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-010-0784-7