Effects of Apolipoprotein E- epsilon 4 and - epsilon 2 in Amnestic Mild Cognitive Impairment and Dementia in Shanghai: SCOBHI-P

• Published in: American journal of Alzheimer's disease and other dementias 2010-05, Vol.25 (3), p.233-238
• Main Authors: Borenstein, Amy R, Mortimer, James A, Ding, Ding, Schellenberg, Gerard D, DeCarli, Charles, Zhao, Qianhua, Copenhaver, Cathleen, Guo, Qihao, Chu, Shugang, Galasko, Douglas, Salmon, David P, Dai, Qi, Wu, Yougui, Petersen, Ronald, Hong, Zhen
• Format: Article
• Language: English
• ISSN: 1533-3175
• DOI: 10.1177/1533317509357736

Objective: To determine apolipoprotein E (APOE)- epsilon 4 and - epsilon 2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China. Methods: A total of 34 MCI and 34 dementia cases were recruited from an urban Memory Disorders Clinic and 32 controls were recruited from a residential community served by the clinic. Apolipoprotein E was genotyped using standard methods. Results: Among controls, frequencies were epsilon 2, 0.11; epsilon 3, 0.84; and epsilon 4, 0.05; among MCI, 0.05, 0.77, and 0.18; and for dementia, 0.02, 0.84, and 0.15, respectively. In education-adjusted models, the odds ratio (OR) = 5.6 for dementia (95% CI = 1.09-29.3) and 4.7 for MCI (95% CI = 0.90-25.2) associated with any epsilon 4 allele. The epsilon 2 allele was inversely associated with dementia (OR = 0.12, 95% CI = 0.013-0.997) and MCI (OR = 0.38, 95% CI = 0.08-1.61). Conclusions: APOE- epsilon 4 increases and - epsilon 2 decreases the risk of dementia vs normal cognition. Similar trends were observed for amnestic mild cognitive impairment (aMCI).