Effect of perphenazine enanthate on open-field test behaviour and stress-induced hyperthermia in domestic sheep

The open-field test (OFT) and stress-induced hyperthermia (SIH) have been used to measure individual differences in fear. The present study has been designed as a pharmacological validation of OFT and SIH as indicators of fear in sheep using perphenazine enanthate (PPZ), a long-acting neuroleptic. T...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2010, Vol.94 (3), p.329-332
Main Authors: Pedernera-Romano, Cecilia, Ruiz de la Torre, José L., Badiella, Llorenç, Manteca, Xavier
Format: Article
Language:English
Subjects:
Animals
Animals, Domestic
Behavior, Animal - drug effects
Behaviour
Biological and medical sciences
Body temperature
Fear
Female
Fever - physiopathology
Medical sciences
Neuroleptic
Neuropharmacology
Open-field test
Perphenazine - analogs & derivatives
Perphenazine - pharmacology
Perphenazine enanthate
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Sheep
Stress, Physiological
Stress-induced hyperthermia
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Summary:The open-field test (OFT) and stress-induced hyperthermia (SIH) have been used to measure individual differences in fear. The present study has been designed as a pharmacological validation of OFT and SIH as indicators of fear in sheep using perphenazine enanthate (PPZ), a long-acting neuroleptic. Twenty four ewes of two breeds, Lacaune and Ripollesa, were tested in an arena measuring 5 m × 2.5 m. Treatment group received one dose of 1.5 mg/kg of PPZ and control group received sterile sesame oil. All animals were tested for 10 min and behaviours were recorded. Rectal temperature was measured at the beginning ( T1) and at the end ( T2) of the test. SIH was defined as the difference between T2 and T1. Sheep were tested on days 1, 2, 3, 4, 7 and 9 after PPZ injection. Variables were analysed using a mixed model. PPZ decreased bleats on days 2, 3, 4 and the SIH response on days 2 and 3. Breed differences were observed. Treated animals showed positive correlations between SIH and bleats; squares entered; attempts to escape and negative correlation between SIH and visits to the food bucket. Our results suggest that behaviour and SIH on the OFT are useful measures of fear in sheep.
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2009.09.013