Parenteral immunization of fish, Labeo rohita with Poly d, l-lactide-co-glycolic acid (PLGA) encapsulated antigen microparticles promotes innate and adaptive immune responses

Immunogenicity of different antigen preparations of outer membrane proteins (OMP) of Aeromonas hydrophila such as Poly d, l-lactide-co-glycolic acid (PLGA) microparticles, oil emulsion, neat OMP and bacterial whole cells were compared through intra-peritoneal injection in fish, Labeo rohita. Among t...

Full description

Saved in:
Bibliographic Details
Published in:Fish & shellfish immunology 2010-02, Vol.28 (2), p.320-325
Main Authors: Behera, T., Nanda, P.K., Mohanty, C., Mohapatra, D., Swain, P., Das, B.K., Routray, P., Mishra, B.K., Sahoo, S.K.
Format: Article
Language:English
Subjects:
Adaptive Immunity - immunology
Aeromonas hydrophila
Aeromonas hydrophila - immunology
Animals
Bacterial Outer Membrane Proteins - immunology
Bacterial Vaccines - immunology
Cyprinidae - immunology
Immune response
Immunity, Innate - immunology
Immunization - veterinary
Infusions, Parenteral
Labeo rohita
Lactic Acid - chemistry
Lactic Acid - immunology
Microparticles
Outer membrane proteins
Particle Size
PLGA
Polyglycolic Acid - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Immunogenicity of different antigen preparations of outer membrane proteins (OMP) of Aeromonas hydrophila such as Poly d, l-lactide-co-glycolic acid (PLGA) microparticles, oil emulsion, neat OMP and bacterial whole cells were compared through intra-peritoneal injection in fish, Labeo rohita. Among these preparations, PLGA encapsulated antigen stimulated both innate and adaptive immune parameters and the immunogenicity exhibited by PLGA microparticles was significantly higher ( p 
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2009.11.009