Metabolic syndrome after risk-reducing salpingo-oophorectomy in women at high risk for hereditary breast ovarian cancer: A controlled observational study

Abstract Surgical menopause may increase the risk of cardiovascular diseases (CVDs). The aim of this study was to determine the risk of metabolic syndrome in women who had undergone risk-reducing salpingo-oophorectomy (RRSO) because of increased risk of hereditary breast ovarian cancer (HBOC). A sam...

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Bibliographic Details
Published in:European journal of cancer (1990) 2009-01, Vol.45 (1), p.82-89
Main Authors: Michelsen, Trond M, Pripp, Are H, Tonstad, Serena, Tropé, Claes G, Dørum, Anne
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers - blood
BRCA1
BRCA2
Breast Neoplasms - blood
Breast Neoplasms - genetics
Breast Neoplasms - surgery
Cardiovascular diseases
Case-Control Studies
Cholesterol, HDL - blood
Fallopian Tubes - surgery
Female
Genes
Genetic Predisposition to Disease
Hematology, Oncology and Palliative Medicine
Humans
Logistic Models
Medical sciences
Metabolic Syndrome - blood
Metabolic Syndrome - etiology
Metabolic syndrome X
Middle Aged
Norway
Oophorectomy
Ovarian Neoplasms - blood
Ovarian Neoplasms - genetics
Ovarian Neoplasms - surgery
Ovariectomy
Pharmacology. Drug treatments
Postoperative Period
Risk
Triglycerides - blood
Tumors
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Summary:Abstract Surgical menopause may increase the risk of cardiovascular diseases (CVDs). The aim of this study was to determine the risk of metabolic syndrome in women who had undergone risk-reducing salpingo-oophorectomy (RRSO) because of increased risk of hereditary breast ovarian cancer (HBOC). A sample of 326 (65% of invited) women at risk of HBOC who had undergone RRSO was compared to 679 women from the general population. Mean follow-up after surgery was 6.5 years (standard deviations [SD] 4.4). RRSO was significantly associated with metabolic syndrome according to the 2005 National Cholesterol Education Program Adult Treatment Panel III criteria (odds ratio [OR] 2.46 [95% confidence interval (CI) 1.63, 3.73]) and according to the International Diabetes Federation criteria (OR 2.49 [CI 1.60, 3.88]), as were increasing age and body mass index (BMI). RRSO in women at risk of HBOC is significantly associated with the metabolic syndrome, and the follow-up after RRSO should take these findings into consideration.
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2008.09.028