Facile synthesis of core intermediates toward sialyl nucleoside mimetics

6-Deoxyphosphonated intermediates, 8 and 12, were efficiently synthesized from d-fructose and sucrose, respectively. These novel intermediates will be useful to synthesize various d-tagato- and fructofuranoside derivatives as inhibitors of sialyl transferase or sialidase.

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Bibliographic Details
Published in:Tetrahedron letters 2009-05, Vol.50 (21), p.2543-2544
Main Authors: Kwon, Hyeok Beom, Itzstein, Mark von, Jung, Kang-Yeoun
Format: Article
Language:English
Subjects:
d-Tagatofuranoside
Epoxy phosphonate
Phosphonated sugar
Sucrose
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Description
Summary:6-Deoxyphosphonated intermediates, 8 and 12, were efficiently synthesized from d-fructose and sucrose, respectively. These novel intermediates will be useful to synthesize various d-tagato- and fructofuranoside derivatives as inhibitors of sialyl transferase or sialidase.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.03.050