Trapping Norovirus by Glycosylated Hydrogels: a Potential Oral Antiviral Drug

Trapped! Hydrogels have potential for use as prophylactic drugs against norovirus infection, as they absorb virus particles with high affinity. Virus entrapped in the hydrogel would be rendered harmless as it is cleared from the body. This approach could be useful in the worldwide fight against vira...

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Bibliographic Details
Published in:ChemMedChem 2006-12, Vol.1 (12), p.1361-1366
Main Authors: Zhang, Yalong, Yao, Qingjia, Xia, Chengfeng, Jiang, Xi, Wang, Peng George
Format: Article
Language:English
Subjects:
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Carbohydrate Conformation
Carbohydrate Sequence
drug design
Enzyme-Linked Immunosorbent Assay
Glycosylation
hydrogels
Hydrogels - chemical synthesis
Hydrogels - chemistry
Hydrogels - pharmacology
Molecular Sequence Data
Norovirus
Norovirus - chemistry
Norovirus - drug effects
oligosaccharides
Particle Size
Structure-Activity Relationship
Surface Properties
viruses
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Description
Summary:Trapped! Hydrogels have potential for use as prophylactic drugs against norovirus infection, as they absorb virus particles with high affinity. Virus entrapped in the hydrogel would be rendered harmless as it is cleared from the body. This approach could be useful in the worldwide fight against viral gastroenteritis outbreaks.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.200600135