Two-component signal transduction as potential drug targets in pathogenic bacteria

Gene clusters contributing to processes such as cell growth and pathogenicity are often controlled by two-component signal transduction systems (TCSs). Specific inhibitors against TCS systems work differently from conventional antibiotics, and developing them into new drugs that are effective agains...

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Bibliographic Details
Published in:Current opinion in microbiology 2010-04, Vol.13 (2), p.232-239
Main Authors: Gotoh, Yasuhiro, Eguchi, Yoko, Watanabe, Takafumi, Okamoto, Sho, Doi, Akihiro, Utsumi, Ryutaro
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics
Bacteria - classification
Bacteria - drug effects
Bacteria - metabolism
Bacteria - pathogenicity
Bacterial Infections - microbiology
Bacterial Proteins - drug effects
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Bacterial - drug effects
Histidine Kinase
Humans
Microbiology
Miscellaneous
Pathology
Protein Kinase Inhibitors - pharmacology
Protein Kinases - drug effects
Protein Kinases - genetics
Protein Kinases - metabolism
Signal Transduction - drug effects
Virulence - drug effects
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Summary:Gene clusters contributing to processes such as cell growth and pathogenicity are often controlled by two-component signal transduction systems (TCSs). Specific inhibitors against TCS systems work differently from conventional antibiotics, and developing them into new drugs that are effective against various drug-resistant bacteria may be possible. Furthermore, inhibitors of TCSs that control virulence factors may reduce virulence without killing the pathogenic bacteria. Previous TCS inhibitors targeting the kinase domain of the histidine kinase sensor suffered from poor selectivity. Recent TCS inhibitors, however, target the sensory domains of the sensors blocking the quorum sensing system, or target the essential response regulator. These new targets are introduced, together with several specific TCSs that have the potential to serve as effective drug targets.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2010.01.008