First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi

Summary Segmental vitiligo is often ascribed to the neurogenic theory of melanocyte destruction, although data about the initial etiopathological events are scarce. Clinical, histopathological and T‐cell phenotypic analyses were performed during the early onset of a segmental vitiligo lesion in a pa...

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Published in:Pigment cell and melanoma research 2010-06, Vol.23 (3), p.375-384
Main Authors: Van Geel, Nanja A. C., Mollet, Ilse G., De Schepper, Sofie, Tjin, Esther P. M., Vermaelen, Karim, Clark, Rachael A., Kupper, Thomas S., Luiten, Rosalie M., Lambert, Jo
Format: Article
Language:English
Subjects:
Antigens - immunology
Biopsy
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - pathology
Cell Separation
etiopathogenesis
halo nevi
histopathology
Humans
Immunophenotyping
melanocyte
Melanocytes - immunology
Melanocytes - pathology
Nevus, Halo - blood
Nevus, Halo - immunology
Nevus, Halo - pathology
Phenotype
Pigmentation - immunology
segmental vitiligo
Skin - immunology
Skin - pathology
vitiligo
Vitiligo - blood
Vitiligo - immunology
Vitiligo - pathology
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Summary:Summary Segmental vitiligo is often ascribed to the neurogenic theory of melanocyte destruction, although data about the initial etiopathological events are scarce. Clinical, histopathological and T‐cell phenotypic analyses were performed during the early onset of a segmental vitiligo lesion in a patient with associated halo nevi. Histopathological analysis revealed a lymphocytic infiltrate, mainly composed of CD8+ T‐cells and some CD4+ T‐cells around the dermo–epidermal junction. Flow cytometry analysis of resident T‐cells revealed a clear enrichment of pro‐inflammatory IFN‐γ producing CD8+ T‐cells in lesional skin compared to the non‐lesional skin. Using human leukocyte antigen‐peptide tetramers (MART‐1, tyrosinase, gp100), increased numbers of T cells, recognizing melanocyte antigens were found in segmental vitiligo lesional skin, as compared with the non‐lesional skin and the blood. Our findings indicate that a CD8+ melanocyte specific T cell‐mediated immune response, as observed in generalized vitiligo, also plays a role in segmental vitiligo with associated halo nevi.
ISSN:1755-1471
1755-148X
DOI:10.1111/j.1755-148X.2010.00703.x