Pathogenesis of bovine brucellosis

Bovine brucellosis is one of the most important zoonotic diseases worldwide, and is of particular significance in developing countries. The disease, which results in serious economic losses due to late term abortion, stillborn and weakly calves, is caused by Gram negative coccobacilli bacteria of th...

Full description

Saved in:
Bibliographic Details
Published in:The veterinary journal (1997) 2010-05, Vol.184 (2), p.146-155
Main Authors: Neta, Alcina V. Carvalho, Mol, Juliana P.S., Xavier, Mariana N., Paixão, Tatiane A., Lage, Andrey P., Santos, Renato L.
Format: Article
Language:English
Subjects:
Abortion, Veterinary - microbiology
Animals
Brucella abortus
Brucella abortus - pathogenicity
Brucellosis
Brucellosis, Bovine - microbiology
Brucellosis, Bovine - pathology
Cattle
Female
Fetus - microbiology
Fetus - pathology
Immunohistochemistry
Male
Pathogenesis
Pregnancy
Pregnancy Complications, Infectious - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bovine brucellosis is one of the most important zoonotic diseases worldwide, and is of particular significance in developing countries. The disease, which results in serious economic losses due to late term abortion, stillborn and weakly calves, is caused by Gram negative coccobacilli bacteria of the genus Brucella. Lesions consist of necrotic placentitis and interstitial mastitis in pregnant cows, and fibrinous pleuritis with interstitial pneumonia in aborted fetuses and newborn calves. This article considers the pathogenesis of Brucella abortus and reviews the ability of the pathogen to invade phagocytic and non-phagocytic host cells, resist the acidified intraphagosomal environment, and inhibit phagosome–lysosome fusion. Significant aspects of innate and adaptive immunity against brucellosis are also discussed.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2009.04.010